Nonmosaic Klinefelter Syndrome Successful
Conception after TESE/ICSI: A case report

SayedElAkhras; Karim Omar ElSaeed; Mohamed Halawa; M Yousef Elsemary; AlyElakhras; Gajek Adam; Vasilios Tanos

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ISSN: 2641-1644

Open Access Journal of Reproductive System and Sexual Disorders

Research Article(ISSN: 2641-1644)

Nonmosaic Klinefelter Syndrome Successful Conception after TESE/ICSI: A case report

Volume 1 - Issue 2

**SayedElAkhras¹, Karim Omar ElSaeed², Mohamed Halawa³, M Yousef Elsemary⁴, AlyElakhras⁵, Gajek Adam⁶ and Vasilios Tanos*⁷**

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- ¹Department of Gynecology and Obstetrics, Omam Hospital, Cairo, Egypt
- ²Department of Urology, Ain Shams University, Cairo, Egypt
- ^3,5Department of Embryology, Omam Hospital, Cairo, Egypt
- ⁴Department of Gynaecology and Obstetrics, ElGalaa Maternity Teaching Hospital, Cairo, Egypt
- ⁶Medical School, St Georges University of London, Cyprus
- ⁷Nicosia University, Director Research and Development Omam Hospital, Egypt
*Corresponding author: Vasilios Tanos, Nicosia University Medical School, and Aretaeio Hospital, Nicosia, Cyprus and Director Research and Development Omam Hospital, Cairo, Egypt

Received: May 25, 2018; Published: June 08, 2018

DOI: 10.32474/OAJRSD.2018.01.000107

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Abstract

Klinefelter syndrome patients are mostly clinically azoospermic, and before the era of TESE, were unable to father genetically their own offspring. Nonmosaic Klinefelter [NMK] patients have chances of fatherhood once sperm is harvested from the epididymal seminiferous tubules and further injected in the ovarian cytoplasm. We report a case of 36y old NMK patient, treated for 3 months with supportive and hormonal medication achieving a pregnancy after TESE/ICSI. This is the first published case of successful conception in a couple with a nonmosaic Klinefelter father in Egypt using TESE/ICSI. Review of the literature for any advantages of mTESE over TESE and conception demonstrated higher pregnancy rates by TESE although the sperm retrieval rate was similar in both techniques.

Conclusion: Nonmosaic Klinefelter patients should no longer be considered sterile.

Keywords: Klinefelter Syndrome; Azoospermia; Male Infertility; TESE; ICSI

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