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ISSN: 2641-1644

Open Access Journal of Reproductive System and Sexual Disorders

Review article(ISSN: 2641-1644)

Luteal Phase Support using Oral Dydrogesterone-a Prospective Treatment for Future Replacing Micronized Vaginal Progesterone

Volume 1 - Issue 4

Kulvinder Kochar Kaur1*, Gautam Allahbadia2 and Mandeep Singh3

  • Author Information Open or Close
    • 1Scientific Director, Centre For Human Reproduction, Punjab, India
    • 2Department of Obstetrics and Gynecology, Mumbai, India
    • 3Department of Neurology, Swami Satyanand Hospital, Punjab, India

    *Corresponding author: Kulvinder Kochar Kaur, Scientific Director, Centre For Human Reproduction 721, G.T.B. Nagar, Jalandhar-144001, Punjab, India

Received: September 03, 2018;   Published: September 10, 2018

DOI: 10.32474/OAJRSD.2018.01.000119

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Although micronized vaginal progesterone is the accepted norm for use in luteal phase support (LPS) in controlled ovarian stimulation (COS) that is used for in vitro fertilization (IVF) cycles, recently importance of oral Dydrogesterone has got the importance in lieu of its oral availability, cheap, no cumbersome side effects and no definitive newer fetal side effects. After the LOTUS 1 trial with a multicenter double placebo, double dummy design it has proved an equal efficacy if not superiority of oral D, over micronized vaginal progesterone and it seems D might soon become the standard of care for LPS in conventional IVF cycles besides its routine indication for recurrent abortions.

Keywords: LPS; COS; IVF; Dydrogesterone; Micronized vaginal progesterone

Abbreviations: LPS: Luteal Phase Support; COS: Controlled Ovarian Stimulation; IVF: In Vitro Fertilization; ET: Embryo Transfer

Abstract| Dydrogesterone(D)-Pharmacology| Advantages of an Oral preparation over other Routes| Problem of Vaginal administration for the Treating Physician| Safety of oral D| Fetal Safety| Cost Effectiveness of D| Conclusions| References|