Assessment of Neurobehavioral and Anti-Aging Effect of the Test Formulation in D-Galactose-Induced aging Dysfunction in Sprague Dawley Rats

Volume 4 - Issue 4

Mahendra Kumar Trivedi¹, Alice Branton¹, Dahryn Trivedi¹, Sambhu Charan Mondal² and Snehasis Jana²*

Received: November 07, 2020;   Published: November 19, 2020

DOI: 10.32474/SJPBS.2020.04.000193

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Abstract

The study aim was to evaluate the neurobehavioral effect of Consciousness Energy Healing Treated test formulation using behavioral test in male Sprague Dawley rats. The test formulation was divided into two parts, one was denoted as control, while the other was treated with Biofield Energy by Mr. Mahendra Kumar Trivedi (the Trivedi Effect®-Consciousness Energy Healing) and defined as the Biofield Energy Treated sample. Besides, three group of animals were also received Biofield Energy Treatment by Mr. Trivedi. In Y-maze test, number of entries was significantly increased in the animals per se received Biofield Energy Treatment (-15 days) group (G6) by 176%, 47.53%, and 66.67% in the start arm, explored arm, and novel arm, respectively as compared to the untreated test formulation group (G4). Further, Biofield Treated animals per se + Biofield Treated test formulation (-15 days) group (G8), showed 100% and 32.74% increased the number of entries in start arm and novel arm, respectively compared to the G4 group. Moreover, percent of alternation behaviour was increased by 7.26% in the G8 as compared to the G4 group. In force swim test (FST) showed the number of climbing was significantly increased by 13.58%, 24.69%, 32.1%, and 40.74% in the G5, G6, G7, and G8, respectively compared to G4 group. Swimming time was significantly increased by 9.34% and 10.31% in the G6 and G9, respectively compared to G4 group. Further, immobility time was significantly decreased by 27.91%, 55.81%, 61.63%, and 11.63% in the G5, G6, G7, and G9, respectively compared to the G4 group. The results of Morris water maze (MWM) test data showed that the escape latency was significantly decreased by 12.06% (session 2), 13.04% (session 3), 14.88% (session 3), and 17.52% (session 3) in the G5, G7, G8, and G9 groups, respectively compared to the G4 group. The resting time was significantly (p≤0.05) decreased by 16.26% (session 3) and 15.45% (session 3) in the G7 and G9, respectively compared to G4 group. Besides, total distance travelled was significantly reduced by 27.23% and 23% (in session 2) in the G5 and G9 groups, respectively compared to the G4 group. The results showed significant reduction of disease progression and disease-related symptoms in the preventive Treatment group per se and/or Biofield Energy Treated Test formulation groups (viz. G6, G7, G8, and G9) comparatively with the disease control group. Therefore, data suggest that Biofield Energy Treatment per se and Biofield Energy Treated test formulation have significant cognition and memory enhencing activity and could be utilized in various aging and neurobehavioral related disorders such as stroke, dementia, multiple sclerosis, acute confusional states (delirium), focal lesion syndromes, frontal lobe syndromes, etc.

Keywords: Biofield energy healing; The trivedi effect®; Neurobehavioral; Force swim test; Spatial memory; Antiaging; Morris water maze; Y-maze test; Antiaging

Abbreviations: FST: Forced Swim Test; NIH/NCCAM: National Institute of Health/National Centre for Complementary and Alternative Medicine; SD: Sprague Dawley; Na-CMC: Sodium Carboxymethyl Cellulose; MWM: Morris Water Maze

Abstract| Introduction| Materials and Methods| Results and Discussion| Conclusion| Acknowledgement| References|