Viral Covid-19 has spreaded all over the World only in a few months and caused much deaths. Covid-19 is belong to coronavirus
family (called also SARS-CoV-2). Virus entry into cell occurs by unification with membrane receptors by releasing viral capsids or by
endocytosis. TNF inhibitors aim to block receptors that bind to intracellular pathways as soluble form or by membrane bounding.
Some TNF-α inhibitors have been used on severe Covid-19 patients nowadays.