Topic- Hemophagocytic Lymphohistiocytosis: A New Foe

Rohit V

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ISSN: 2637-4722

Progressing Aspects in Pediatrics and Neonatology

Mini Review(ISSN: 2637-4722)

Topic- Hemophagocytic Lymphohistiocytosis: A New Foe

Volume 1 - Issue 2

**Rohit Vohra¹* and Dr Minakshi²**

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- ¹Department of Pediatric emergency and critical care medicine, Sir Ganga Ram Hospital, India
- ²Department of Pediatric Hematology and Oncology, Sir Ganga Ram Hospital, India
*Corresponding author: Rohit Vohra, Department of Pediatric emergency and critical care medicine, Sir Ganga Ram Hospital, New Delhi, India

Received: February 05, 2018; Published: February 16, 2018

DOI: 10.32474/PAPN.2018.01.000108

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Abstract

Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threatening syndrome of excessive immune activation. It commonly affects infants from birth to 18 months of age, but the disease can be seen in children and adults of all ages. HLH can occur as a familial or sporadic disorder, and it can be triggered by a variety of events that disrupt immune homeostasis. Prompt recognition of the disease and initiation of treatment is essential for the survival of affected patients [1]..

Keywords: HLH; NK cells; Immune system

Abbrevations: HLH: Hemophagocytic lymphohistiocytosis; NK: Natural killer; CTLs: cytotoxic T- lymphocytes

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