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Research Article(ISSN: 2637-4723)

A Profile of Microbial Isolates and Antibiotic Susceptibility Patterns in Neonatal Sepsis at a Tertiary Care Centre in South India - A Post HOC Analysis

Volume 1 - Issue 5

Santosh Kumar Kamalakannan1*, NC Manikandan2 and Sankavi Santosh Kumar3

  • Author Information Open or Close
    • 1Department Of Neonatology, Saveetha Medical College and Hospital, India
    • 2Department Of Pediatrics, Madras Medical College and Research Institute, India
    • 3Department Of Physical and Rehabilitation Medicine, Madras Medical College, India

    *Corresponding author: Santosh Kumar Kamalakannan, Department of Neonatology, Saveetha medical college and hospital, Thandalam, Chennai, India

Received: Ocotber 02, 2018;   Published: Ocotber 08, 2018

DOI: 10.32474/PAPN.2018.01.000123

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Background: Neonatal sepsis is a common problem in Neonatal intensive care units. Neonatal sepsis is classified as early onset and late onset based on the time of occurrence of clinical symptoms in the neonate. Organisms causing sepsis in neonates vary from unit to unit and from time to time within the same unit. Study of microbial pattern and their antibiotic sensitivity pattern is essential part of managing septic neonates.

Methods: The study was carried out in Govt Kilpauk medical college hospital between October 2010 to October 2012

Results: A total of 207 newborns with clinical sepsis were admitted. Blood culture was positive in 88 out of the 207 cases (42.51%) Klebsiella is the commonest organism causing sepsis (45%) in our Neonatal Intensive Care Unit. Other gram-negative isolates included Escherichia Coli (31%), Pseudomonas (6%), Enterobacter (1%) and Acinetobacter (2%). The Gram-positive organisms grown were Coagulase Positive and Coagulase negative Staphylococci (8%), Group B Beta Hemolytic Streptococcus (5%) and Enterococcus (2%). Late-onset sepsis cases were found to be 1.5 times higher than early-onset sepsis. Out of 88 cases, 34(38.64%) had early-onset sepsis and 54(61.36%) had late-onset sepsis.

Conclusion: A insight knowledge of the microbial isolate and their sensitivity pattern in Neonatal intensive care unit is essential in preventing mortality. The commonly pathogens isolated in the study are found to be resistant to the commonly used antibiotics.

Keywords: Neonatal Sepsis; Antibiotic Sensitivity; Gram Positive Organism; Multi Drug Resistant Organisms; Antibiotic Stewardship

Abstract| Introduction| Case Report| Discussion| Conclusion| References|


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