Platelet Mass Index as A New Factor in Tinnitus Etiology
Volume 6 - Issue 4
Ahmet Doblan*
- 1Department of Otorhinolaryngology, SBÜ Mehmet Akif Inan Training and Research Hospital, Turkey
Received: May 15, 2021 Published: May 28, 2021
Corresponding author: Ahmet Doblan, Member Faculty, MD, ENT-HNS Specialist, SBÜ Mehmet Akif İnan Training and Research
Hospital, Şanlıurfa, Turkey
DOI: 10.32474/SJO.2021.06.000243
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Abstract
Introduction: Although there are numerous studies on the etiology and treatment of tinnitus, most have not provided a
definitive conclusion. Vascular and hematological abnormalities play an important role in the etiology of tinnitus. In this study, we
aimed to evaluate the usability of the platelet mass index as a new inflammatory marker in patients with tinnitus.
Material and Method: The detailed medical records (examination notes, drug use, radiological evaluations, audiological
evaluations, and previous vascular-cardiac-autological surgical procedures) of 1,079 tinnitus patients presenting to our clinic
between January 2019 and May 2020 were examined, and a retrospective hemogram evaluation was performed in 176 patients
meeting the inclusion criteria in tinnitus group. As the control group, 190 people were selected from individuals that presented to
the outpatient clinic without otologic complaints. Age, gender, erythrocyte (RBC), hemoglobin (HGB), neutrophil (NEU), lymphocyte
(LYM), platelet (PLT) and mean platelet volume (MPV) were examined, and the neutrophil-lymphocyte ratio (NLR), plateletlymphocyte
ratio (PLR) and platelet mass index (PMI) were calculated, and the results were compared between the tinnitus and
control groups.
Statistical analysis and results: There were no statistically significant difference between the control and tinnitus groups
in terms of mean age, gender, and RBC, NEU, LYM, PLR and NLR levels (p>0.05 for all). The HGB and MPV levels were significantly
higher (p<0.001 for both) and the PLT level was significantly lower (p = 0.033) in the tinnitus group compared to the control group.
In addition, the PMI value of the tinnitus group was statistically significantly higher than that of the control group (p<0.001).
Discussion and conclusion: This study was the first to investigate PMI in tinnitus patients, and this index was found to be
higher in this patient population. This supports the idea that PMI can be used as an inflammatory marker in tinnitus. PMI can reveal
platelet functions more clearly since it provides the opportunity to simultaneously evaluate the volume and number of platelets.
However, since the relationship of PMI with tinnitus severity was not examined in this study, further detailed studies are needed
on this subject.
Keywords:Tinnitus; platelet mass index; inflammatory marker; mean platelet volume; platelet
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