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ISSN: 2641-1709

Scholarly Journal of Otolaryngology

Research Article(ISSN: 2641-1709)

Correlation f Clinical Diagnosis of Squamous Cell Carcinoma or Lymphoma and Confirmatory Immunohistochemistry Results of Cytokeratin (CK) or Leukocyte Common Antigen (LCA) Among Patients with Undifferentiated Carcinoma of the Nasopharynx

Volume 5 - Issue 2

Candice Que Ansorge* and Emmanuel Tadeus S Cruz

  • Author Information Open or Close
    • Department of Otorhinolaryngology – Head and Neck Surgery, Manila Central University Filemon D Tanchoco Medical Foudation, Philippines

    *Corresponding author: Candice Que Ansorge, Department of Otorhinolaryngology – Head and Neck Surgery, Manila Central University Filemon D Tanchoco Medical Foundation, Philippines

Received: September 15, 2020;   Published: September 28, 2020

DOI: 10.32474/SJO.2020.05.000210

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Abstract

Objective: To determine the correlation between clinical diagnosis (Squamous cell carcinoma or Lymphoma) and immunohistochemical results (Cytokeratin or Leukocyte Common Antigen) among patients with undifferentiated nasopharyngeal malignancy.

Study Design: Analytical, cohort study

Setting: Tertiary private hospital in Metro Manila Sample population and Methodology: Patients diagnosed of undifferentiated nasopharyngeal malignancy for the recent five (5) years were included in the study. Clinical diagnosis of nasopharyngeal squamous cell carcinoma or lymphoma was correlated with positive immunohistochemistry of cytokeratin (CK) and Leukocyte Common Antigen (LCA) respectively.

Results and Conclusion: The results showed that there was a significant association between the clinical diagnosis and immunochemistry results (p value 0.05). Among the 23 patients with clinical diagnosis of squamous cell carcinoma, only 19 patients (82.6%) were confirmed with CK reactivity while 4 cases were reactive with LCA. Among the 7 patients with clinical diagnosis of Lymphoma, only 4 patients (57.1%) were confirmed with LCA reactivity while 3 were positive for cytokeratin. A total of 22 patients were interpreted as cytokeratin positive (73.7%) and 8 patients were LCA positive (26.3%). Hence, there was a relatively fair association between clinical diagnosis of lymphoma and confirmatory LCA immunostain.

Keywords: Nasopharyngeal cancer; undifferentiated carcinoma; squamous cell cancer; lymphoma; LCA, cytokeratin

Abbreviations:LCA: Leukocyte Common Antigen; CK: Cytokeratin; IHC: Immunohistochemistry; NPCA: Nasopharyngeal Carcinoma

Abstract| Introduction| Review of Related Literature| Sample Population & Methodology| Results| Discussion| Conclusion| References|

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