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- Department of Otorhinolaryngology – Head and Neck Surgery, Manila Central University Filemon D Tanchoco Medical Foudation,
Philippines
*Corresponding author:
Candice Que Ansorge, Department of Otorhinolaryngology – Head and Neck Surgery, Manila Central
University Filemon D Tanchoco Medical Foundation, Philippines
Received: September 15, 2020; Published: September 28, 2020
DOI: 10.32474/SJO.2020.05.000210
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Abstract
Objective: To determine the correlation between clinical diagnosis (Squamous cell carcinoma or Lymphoma) and
immunohistochemical results (Cytokeratin or Leukocyte Common Antigen) among patients with undifferentiated nasopharyngeal
malignancy.
Study Design: Analytical, cohort study
Setting: Tertiary private hospital in Metro Manila Sample population and Methodology: Patients diagnosed of undifferentiated
nasopharyngeal malignancy for the recent five (5) years were included in the study. Clinical diagnosis of nasopharyngeal squamous
cell carcinoma or lymphoma was correlated with positive immunohistochemistry of cytokeratin (CK) and Leukocyte Common
Antigen (LCA) respectively.
Results and Conclusion: The results showed that there was a significant association between the clinical diagnosis and
immunochemistry results (p value 0.05). Among the 23 patients with clinical diagnosis of squamous cell carcinoma, only 19 patients
(82.6%) were confirmed with CK reactivity while 4 cases were reactive with LCA. Among the 7 patients with clinical diagnosis
of Lymphoma, only 4 patients (57.1%) were confirmed with LCA reactivity while 3 were positive for cytokeratin. A total of 22
patients were interpreted as cytokeratin positive (73.7%) and 8 patients were LCA positive (26.3%). Hence, there was a relatively
fair association between clinical diagnosis of lymphoma and confirmatory LCA immunostain.
Keywords: Nasopharyngeal cancer; undifferentiated carcinoma; squamous cell cancer; lymphoma; LCA, cytokeratin
Abbreviations:LCA: Leukocyte Common Antigen; CK: Cytokeratin; IHC: Immunohistochemistry; NPCA: Nasopharyngeal
Carcinoma
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