Age-related hearing loss (ARHL) or presbycusis is the most prevalent sensory deficit in the elderly. This progressive hearing
impairment leads to social isolation. Currently, our understanding of ARHL is very limited. In this review, we have chosen to focus
on recent work that has improved our understanding of the cellular and molecular mechanisms that may cause age-related loss
of sensory and neural cells in the cochlea. Our goal here is to give an overview of recent progress towards understanding these
phenomena. In addition, we discuss future prospects for advances in our understanding of genetic susceptibility, pathology, and
potential therapeutic approaches in ARHL.