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ISSN: 2641-1709

Scholarly Journal of Otolaryngology

Review Article(ISSN: 2641-1709)

Age-Related Hearing Loss: Recent Findings and Emerging Questions

Volume 4 - Issue 1

Esperanza Cuadrado1, Carolina Sánchez Rodríguez2* and Ricardo Sanz Fernández2,3/strong>

  • Author Information Open or Close
    • 1Department of Clinical Analysis, University Hospital of Getafe, Spain
    • 2Faculty of Biomedical and Health Sciences, European University of Madrid, Spain
    • 3Department of Otorhinolaryngology, University Hospital of Getafe, Spain

    *Corresponding author: Carolina Sánchez Rodríguez, Faculty of Biomedical and Health Sciences, European University of Madrid, Spain

Received: February 08, 2020;   Published: February 19, 2020

DOI: 10.32474/SJO.2020.04.000177

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Age-related hearing loss (ARHL) or presbycusis is the most prevalent sensory deficit in the elderly. This progressive hearing impairment leads to social isolation. Currently, our understanding of ARHL is very limited. In this review, we have chosen to focus on recent work that has improved our understanding of the cellular and molecular mechanisms that may cause age-related loss of sensory and neural cells in the cochlea. Our goal here is to give an overview of recent progress towards understanding these phenomena. In addition, we discuss future prospects for advances in our understanding of genetic susceptibility, pathology, and potential therapeutic approaches in ARHL.

Keywords: Age-related hearing loss; presbycusis; regenerative therapies; antioxidants; inflammaging; oxidative stress

Abbreviations: ARHL: Age-related hearing loss; WHO: World Health Organization; GPx: Glutathione peroxidase; NAC: N-acetyl- L-cysteine; VEGF: Vascular Endothelial Grow Factor; BMT: Bone Marrow Transplantation; LGRs: Leucine-rich repeat-containing G-protein coupled Receptors; iPSCs: Induced pluripotent stem cells

Abstract| Introduction| Molecular Mechanisms of Arhl Therapeutic Perspectives| Conclusion| Acknowledgment| References|