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- 1Department of Clinical Analysis, University Hospital of Getafe, Spain
- 2Faculty of Biomedical and Health Sciences, European University of Madrid, Spain
- 3Department of Otorhinolaryngology, University Hospital of Getafe, Spain
*Corresponding author:
Carolina Sánchez Rodríguez, Faculty of Biomedical and Health Sciences, European University of Madrid,
Spain
Received: February 08, 2020; Published: February 19, 2020
DOI: 10.32474/SJO.2020.04.000177
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Abstract
Age-related hearing loss (ARHL) or presbycusis is the most prevalent sensory deficit in the elderly. This progressive hearing
impairment leads to social isolation. Currently, our understanding of ARHL is very limited. In this review, we have chosen to focus
on recent work that has improved our understanding of the cellular and molecular mechanisms that may cause age-related loss
of sensory and neural cells in the cochlea. Our goal here is to give an overview of recent progress towards understanding these
phenomena. In addition, we discuss future prospects for advances in our understanding of genetic susceptibility, pathology, and
potential therapeutic approaches in ARHL.
Keywords: Age-related hearing loss; presbycusis; regenerative therapies; antioxidants; inflammaging; oxidative stress
Abbreviations: ARHL: Age-related hearing loss; WHO: World Health Organization; GPx: Glutathione peroxidase; NAC: N-acetyl-
L-cysteine; VEGF: Vascular Endothelial Grow Factor; BMT: Bone Marrow Transplantation; LGRs: Leucine-rich repeat-containing
G-protein coupled Receptors; iPSCs: Induced pluripotent stem cells
Abstract|
Introduction|
Molecular Mechanisms of Arhl
Therapeutic Perspectives|
Conclusion|
Acknowledgment|
References|