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ISSN: 2638-6003

Orthopedics and Sports Medicine: Open Access Journal

Research Article(ISSN: 2638-6003)

Effects of Circadian Rhythm Disorder on Learning and Memory in Mice

Volume 2 - Issue 3

Huang Changquan* and Liu Qingxiu

  • Author Information Open or Close
    • The Third Hospital of Mianyang, China

    *Corresponding author: Huang Changquan, The third hospital of Mianyang, Sichuan 621000, China

Received: December 05, 2018;   Published: December 13, 2018

DOI: 10.32474/OSMOAJ.2018.02.000137

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Objective: The change of learning and memory was explored in circadian rhythm disorder mice induced by irregular light/ dark cycle.

Methods: Mice model of circadian rhythm disorder induced by irregular light/dark cycle. Twenty-four male ICR mice were raised under different light/dark cycles including LD 12h/12h (Group 1: Normal circadian rhythm group), light 3h next to darkness 5h and light 5h next to dark 3h alternate every other day (Group 2: Circadian rhythm disorder group). The twenty-four ICR mice were randomly assigned to these two groups and feed six months. Each group included twelve. Morris Water-maze task was used as the judging criteria for spatial learning and memory.

Result: The learning and memory was significantly decreased in circadian rhythm disorder mice induced by irregular light/ dark cycle (P<0.05).

Conclusion: Circadian rhythm disorders impaired learning and memory.

Keywords: Circadian Rhythm; Light/Dark Cycle; Learning and Memory; Mice

Abstract| Introduction| Materials & Methods| Results| Discussion| Conclusion| References|


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