Implication of Intrinsic Intraocular Risk Factors at Ocular Blood Flow to Primary Glaucoma

Volume 1 - Issue 1

Edward Ath Skoufis* and Konstantinos Diamantopoulos

Received: January 24, 2018;   Published: February 08, 2018

DOI: 10.32474/TOOAJ.2018.01.000105

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF

Abstract

Purpose:To assess the implication of intrinsic intraocular risk factors at ocular blood flow (OBF) to primary glaucoma (POAG).

Method:In a retrospective control study included 51 consecutive patients, mean age 50, 5±7, in follow-up 2008-2012 divided in control group (CG) 15 patients without POAG, group A (GRA) 15 patients with POAG, group B (GRB) 21 patients with POAG, 9 of them with disc hemorrhage (DH) and 12 with peripapillary atrophy (PPA). We performed baseline glaucoma examination including monitoring pulsatile ocular blood flow (POBFA), pulse amplitude (PA), central corneal thickness (CCT), OCT and visual field (VF) examination. Exclusion criteria: Previous ocular trauma and surgery, pathologies with evident VD. Paired T-test and linear regressions used for statistical analysis.

Results:Our findings indicated a strong correlation between OBFA, IOP and an interrelation between POAG and intrinsic risk factors, DH and PPA (P=0,001). In GRB versus CG,GRA POBF were very sensible and fluctuated depending on the intraocular VD.CCT and IOP changes (P=0,002), showed the abnormality auto regulation(r=0,650). In GRB the POBF and PA were lower ≥8% than other subgroups (P<0,001). LATANOPROST with IOP reduction from baseline 30, 8%, POBF improved 16,6%, PA 10% was the best therapy in GRA. In GRB the switch therapy DORZOLAMIDE + LATANOPROST, DORZOLAMIDE + BIMATOPROST IOP reduction 33.0% from baseline, POBF improved 36%, PA 22%, with added therapy NILVADIPIN 60 mgr + GINKGO BILOBA 150 mg, VISIONACE plus the hemodynamic parameters further improved ≥5%.

Keywords: Vascular Dysregulation; pulsatile ocular blood flow; Pulse Amplitude; Factor Risk , Disc Hemorrhage, Peripapillary Atrophy; Primary Glaucoma, Hemodynamic Parameters, Selective Therapy.

Abbrevations: VDR: Vascular Dysregulation, POAG: Primary Glaucoma; POBF: Pusatile Ocular Blood Flow; PA: Pulse Amplitude; DH: Disc Hemorrhage; PPA: Peripapillary Atrophy; CCT: Central Corneal Thickness; VF: Visual Field

Abstract| Introduction| Method| Results| Discussion| Conclusion| References|