A number of Schiff’s base derivatives for N’-methylene-1H-indole-2-carbohydrazide have been designed and evaluated in-silico
for their cyclooxygenase (COX) inhibition ability. All molecules were docked to the active site of both COX-1 and COX-2 using the
Auto Dock 4.2 software. All studied compounds showed high docking score against both COX-1 and COX-2. The docking scores and
binding energy of the investigated compounds were found to be very promising as cyclooxygenase inhibitor and consequently as
non-steroidal analgesic agents.