Background: The aim of this pilot study was to compare the intracranial pressure (ICP) control between the continuous lumbar
drainage (CLD) and repeated lumbar puncture (LP) on the patients with HIV-associated Cryptococcal Meningitis (CM).
Methods: From January 2017 to January 2019, a total of forty patients with HIV-associated CM patients were randomized and
allotted into CLD or repeated LP groups, respectively. During the first two weeks of the treatment, either CLD or LP were used to
control the ICP pressure except the routine antifungal therapy was given following the consensus and guidelines of CM. The ICP
pressure, protein concentration and cell count from CSF were assayed and compared between the two groups.
Result: All the patients were survived. At the day 14 post treatment, a drop in ICP was observed among patients and clinical
symptoms were relieved. The ICP of CLD group was significantly lower than those of LP group(P<0.05). The protein concentration
and cell count from CSF of CLD group were significantly less than LP group(P<0.05).
Conclusions: CLD is a simple, safe or the first-choice control of intracranial hypertension in the patients with HIV associate
cryptococcal meningitis. Especially, for patients were treated in primary and/or secondary hospitals located at the low-middle