Cefpodoxime Proxetil and its By-Products: A
Comparative Study as Per EP-7
Volume 1 - Issue 2
Krishnasarma pathy*
-
Author Information
Open or Close
- Head QC/QAIPL research centre, Department of pharmacology, India
*Corresponding author:
Krishnasarma pathy, Head QC/QAIPL research centre, Department of pharmacology, India
Received: August 16, 2018; Published: August 28, 2018
DOI: 10.32474/LOJMS.2018.01.000110
Full Text
PDF
To view the Full Article Peer-reviewed Article PDF
Abstract
Cephalosporins are the highly used Broad-spectrum antibiotics, belong to β-lactam class. Cephalosporins resemble penicillin
in that they have a β-lactam structure, but the five-member thiazolidine ring characteristic of the penicillin is replaced by a sixmember
dihydrothiazine ring. The bactericidal action of beta lactam antibiotics is directly attributable to their ability to react with
PBP’s. The research work relates to a by-products during process for the industrial manufacture of Cefpodoxime Proxetil. The
drug is registered in USP and belongs to 3rd generation drug. It was discovered by Brotzu in fungus Cephalosporium Acremonium
which produces a chemical which show antimicrobial activity. Abraham isolated the three fragmentation patterns of cefpodoxime
proxetil. Data from this systematic study will help improve the safety and quality of cefpodoxime proxetil types of cephalosporin
antibiotics cephalosporin P, cephalosporin N, cephalosporin C.7-ACA is widely used as the substrate for synthesizing cephalosporin
antibiotics. Modification of the 7-ACA side-chains resulted in the development of useful antibiotic agents, and the first agent is
Cephalothin (cefalotin) was launched by. Eli Lilly Company in 1964 There are many patents which gives the procedure of Synthesis
of Cefpodoxime ProxetilStability of three Cefpodoxime proxetil products available in indian market at fridge temperatures (2-8 °C),
room temperature (25 °C) and elevated temperature (42 °C). Flow properties, rheological and the physicochemical parameters of
both powder and reconstituted powder were used to evaluate the stability of different brands of Cefpodoxime proxetil available in
india. The powder of stability samples was eluted through a C18 column with formic acid-methanol-water as the mobile phase. In
total, 15 impurities were characterized in commercial samples, including 7 known impurities and 8 new impurities. The structures
of these unknown compounds were deduced via comparison.
Abstract|
Introduction|
Results and Discussion|
Conclusion|
References|