In-Silico Evaluation Of Lamotrigine Schiff Base Of
Cinnamonaldehyde And Its Metal Coordinates At Voltage
Gated Sodium Channel
Volume 4 - Issue 5
Saima Najm*
- Faculty of Pharmacy, Lahore College of Pharmaceutical Sciences, Lahore, Pakistan
Received: October 29, 2021; Published: November 12, 2021
*Corresponding author: Saima Najm, Faculty of Pharmacy, Lahore College of Pharmaceutical Sciences, Lahore, Pakistan
DOI: 10.32474/MAMS.2021.04.000199
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Abstract
Lamotrigine belongs to a class of phenyltriazine compounds,
chemically unrelated to other anticonvulsants [1]; used to control
seizures and convulsions of various grades [2]. The antiepileptic
effect of LTG entails from its binding with the voltage gated sodium
channels (VNaC) and thus inhibiting the release of endogenous
amino acids and acetylcholine [3,4]. Schiff bases of antiepileptic
drugs protect against seizures through variety of cellular targets,
like synaptic vesicle protein, neurotransmitter metabolic enzyme,
neurotransmitter transporter and ion channels [5]. A homology
model of VNaC was prepared for molecular docking studies of
lamotrigine [6]. Docking of metal derived schiff base ligand is a
new approach in computational chemistry; it predicts the binding
affinity of small molecules with receptor that results in new
complex with overall minimum energy [7,8].
Introduction|
Methodology /Molecular Modeling|
Results and Discussion|
Conclusion|
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