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ISSN: 2641-6921

Modern Approaches on Material Science

Short Communication(ISSN: 2641-6921)

In-Silico Evaluation Of Lamotrigine Schiff Base Of Cinnamonaldehyde And Its Metal Coordinates At Voltage Gated Sodium Channel Volume 4 - Issue 5

Saima Najm*

  • Faculty of Pharmacy, Lahore College of Pharmaceutical Sciences, Lahore, Pakistan

Received: October 29, 2021;   Published: November 12, 2021

*Corresponding author: Saima Najm, Faculty of Pharmacy, Lahore College of Pharmaceutical Sciences, Lahore, Pakistan

DOI: 10.32474/MAMS.2021.04.000199

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Abstract

Lamotrigine belongs to a class of phenyltriazine compounds, chemically unrelated to other anticonvulsants [1]; used to control seizures and convulsions of various grades [2]. The antiepileptic effect of LTG entails from its binding with the voltage gated sodium channels (VNaC) and thus inhibiting the release of endogenous amino acids and acetylcholine [3,4]. Schiff bases of antiepileptic drugs protect against seizures through variety of cellular targets, like synaptic vesicle protein, neurotransmitter metabolic enzyme, neurotransmitter transporter and ion channels [5]. A homology model of VNaC was prepared for molecular docking studies of lamotrigine [6]. Docking of metal derived schiff base ligand is a new approach in computational chemistry; it predicts the binding affinity of small molecules with receptor that results in new complex with overall minimum energy [7,8].

Introduction| Methodology /Molecular Modeling| Results and Discussion| Conclusion| References|

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