Role of Adiponectin in Immunity; Implications for Infectious Diseases and Cancer

Volume 1 - Issue 3

Sze Ping Tan¹, Alexander David Saleh² and Peng Hong Tan²*

Received: September 10, 2019;   Published: September 17, 2019

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Abstract

Adipose tissues are not only simply dormant storage depots, but they are dynamic and highly active organs. One of soluble molecules generated by adipocytes is adiponectin (APN). It has been shown to have direct anti-diabetic and anti-atherogenic properties. The role of APN in immunity has been subjected to many controversies lately. Therefore, this review addresses all controversies associated with the effect of APN on the immunity critically. Overall, the evidence supports that APN receptor signaling on the immune cells can promote immune regulation and induce antigen-specific tolerance. This may have significant implications for treatment of many diseases includes cancer, inflammatory related conditions and infectious diseases.

Keywords: Adiponectin; AdipoR1 and AdipoR2; Adaptive immunity and Innate Immunity

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