Possible Role of Inadequate Quantities of
Intra-Thyroidal Bromine, Calcium and Magnesium
in the Etiology of Female Subclinical Hypothyroidism
Volume 1 - Issue 3
Zaichick Vladimir1* and Zaichick Sofia2
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- 1Radionuclide Diagnostics Department, Medical Radiological Research Centre, Russia
- 2Laboratory of Dr. Gabriela Caraveo Piso, Feinberg School of Medicine, Northwestern University, USA
*Corresponding author:
V Zaichick, Medical Radiological Research Centre, Korolyev St.4, Obninsk 249036, Kaluga Region, Russia
Received: January 20, 2018; Published: February 05, 2018
DOI: 10.32474/IGWHC.2018.01.000113
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Abstract
Objective: Subclinical hypothyroidism does affect fertility. The prevalence of subclinical hypothyroidism is 10-15 times more
common in women than in men. Many chemical elements play important role in thyroid function and fertility. The aim of this exploratory
study was to evaluate whether significant differences of chemical element contents exist between female and male thyroids and how
they can be related to the etiology of subclinical hypothyroidism.
Methods: Thyroid tissue levels of Br, Ca, Cl, I, K, Mg, Mn, and Na were prospectively evaluated in 105 healthy persons (33 females
and 72 males). Tissue samples were used for chemical element measurements, employing instrumental neutron activation analysis with
high resolution spectrometry of short-lived radionuclides.
Results: It was found that the Br thyroid content of females was significantly higher than that of males, while the Ca and Mg contents
were lower.
Conclusion: Inappropriate content of intra-thyroidal Br, Ca and Mg can be associated with the etiology of female subclinical
hypothyroidism.
Keywords: Subclinical hypothyroidism; Female Thyroid; Chemical Elements; Neutron activation analysis
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