Alexandra Sack1, Jayme Sack2 and Hari Tunuguntla3*
Received:June 17, 2019; Published: June 24, 2019
*Corresponding author:Hari Tunuguntla, Department of Surgery and Urology, Rutgers Robert Wood Johnson Medical School, USA
Gastrointestinal disorders currently plague millions of Americans and place an immense physical, emotional, and financial burden on society. The conventional medicine paradigm produces modest effects but are often accompanied with adverse side effects as well as increased healthcare utilization. Thus, the demand for alternative therapies is increasing. In the event that conventional medicine offers no satisfactory solution, research provides consistent and compelling evidence for the efficacy of acupuncture as a safe and cost-effective alternative approach to alleviating symptoms associated with digestive dysfunction. This review discusses the pathophysiology of common gastrointestinal disorders and the mechanisms underpinning the regulatory effect of acupuncture. Using principles of Traditional Chinese Medicine, we explain the therapeutic benefits of acupuncture and its’ ability to restore the body’s internal equilibrium and elicit a return to health. Lastly, we conclude with suggestions for optimizing long-term gastrointestinal health and disease prevention through a whole-body approach and healthy lifestyle modifications. We hope to unveil acupuncture as an effective alternative treatment for treating gastrointestinal disease.
Keywords: Acupuncture; Acupoints; QI; Gut; Yin; Yang; Eastern; Western
Abbreviations: TCM: Traditional Chinese Medicine; IBD: Inflammatory Bowel Disease; IBS: Irritable Bowel Syndrome; PCNA: Proliferating Cell Nuclear Antigen; GI: Gastrointestinal
According to the National Institute of Health, more than 60 million Americans were diagnosed with digestive diseases in 2004 resulting in nearly $142 billion expended on direct and indirect costs . Conventional pharmacological treatments have shown to produce modest effects but are costly, run the risk of adverse side effects, and often only provide temporary relief. Gastrointestinal (GI) disorders significantly impair health-related quality of life and work productivity as well as dramatically increase consumption of medical resources. These burdens warrant increasing attention towards the efficacy of alternative therapies for reducing the adverse symptoms that accompany GI diseases. Traditional Chinese Medicine (TCM) and conventional western medicine were long considered two distinct and independent medical models. While western medicine aims to treat disease symptoms using modern medications and procedures, TCM employs a more holistic approach that relies on natural remedies and therapies to restore balance in the body. Acupuncture has been used for thousands of years to treat a variety of illnesses, but it is today’s advanced technology that has allowed us to better understand the mechanisms underpinning the efficacy of this ancient healing method. Research provides promising scientific evidence that acupuncture is a safe and cost-effective approach to alleviating symptoms associated with digestive dysfunction. Acupuncture should not be visualized as competition to treatment modalities of western Medicine, but rather its clinical applications may better focus on conditions for which the conventional medicine has no satisfactory solution. This review will elucidate the current research surrounding the efficacy of acupuncture for treating various gastrointestinal disorders and its symptomatology.
Researchers at the Ziamen University elucidate the possible mechanisms underlying common GI disorders which include a number of substances, notably proliferating cell nuclear antigen (PCNA), substance P, and neurotensin. These biomolecules play a vital role in regulating gastric motility, preserving the intestinal epithelial barrier, inhibiting intestinal inflammation, and protecting gastric mucosa. Acupuncture balances the levels of these biomarkers by either stimulating or suppressing the expression of PCNA, substance P, and neurotensin that encourages gastrointestinal mucosal epithelial growth, reduces gastric acid excretion and promotes healthy digestive motility . The therapeutic effects of acupuncture may also result from its ability to regulate the neuroendrocrine immune system and activate the cholinergic antiinflammatory-dependent pathway, which aids in the preservation of intestinal barrier integrity and optimizes organ function .
In TCM, the human body is visualized as a small universe, a microcosm, within a larger universe, a macrocosm, whereby inputs of the macrocosm (food, air, medication or stimuli arousing the five senses) affect qualities of the body’s energy field. Per the traditional Chinese medical texts, the human body contains a vital life energy, or qi, that circulates to every part of the body through an intricate channel network known as the meridian system. There are twelve primary meridians in the human body: six yang meridians on the posterior body and six yin meridians on the anterior body (Figure 1). There are also eight extraordinary meridians. Positioned along these meridians are more than 300 acupuncture points (i.e. acupoints), located on regions of the dermis with low electrical resistance and close to nerve bundles. Acupuncture utilizes a stainless-steel needle to stimulate these acupoints, which each contain a specific therapeutic action. Furthermore, stimulating a combination of acupoints can elicit varied healing effects. This stimulation of the acupoint(s) promotes the circulation of qi and helps to restore the steady internal physical and chemical milieu within the human body. In optimal health, qi harmoniously flows through the meridians to provide the body with the instructional intelligence required to maintain normal physiological activity and balance bodily functions. According to TCM, when disruptions of the flow of qi through the meridian pathways occur due to insufficient or stagnant qi, patterns of organ disharmony will ensue resulting in pain and/or disease. Another important theory in TCM is the concept of dualism represented by the symbols, yin and yang. These two opposing forces are complementary and remain in constant flux in order to maintain balance within the body. According to Chinese philosophy, any disharmony in proportion of yin and yang will result in patterns of hyper- or hypoactivity within the body and contribute to the development of a diseased state. Therefore, one unique property of acupuncture is that the same stimuli applied to the same acupuncture point can induce opposite regulatory responses under different physiological conditions. In other words, stimulation of a specific acupoint can either increase insufficient qi, decrease excessive qi, circulate stagnant qi, or stabilize disharmonious qi depending on the individual’s unique pathophysiology. For example, the acupoint that runs along the large intestine meridian has been shown to promote gastric peristalsis in individuals with low initial gastric motility and suppress peristalsis in individuals with active initial motility . This dual regulatory feature of acupuncture aids in restoring the harmonious flow of qi, rebalancing patterns of disharmony, and eliciting a return to health. This is the basis of acupuncture theory.
The most common acupuncture points used to treat symptoms associated with digestive disorders include those of the stomach (Figure 2) and large intestine (Figure 3). These points are generally treated in combination with other points and/or in conjunction with moxibustion and herbs. The exact treatment plan will depend on the specific diagnosis of each patient, based on diagnostic procedures (i.e. tongue, appearance, heart rate, and other vital signs). Rather than treating primary symptoms, TCM adopts a holistic approach that addresses the complex patterns of disharmony in the body.
Although acupuncture is best known for its analgesic and anesthetic properties, numerous randomized controlled trials, systematic reviews and meta-analyses have documented its clinical efficacy for treating a number of acute and chronic digestive conditions such as peptic ulcer disease, irritable bowel syndrome (IBS), chronic atrophic gastritis, and inflammatory bowel disease (IBD) [5-7]. The most common causative factors of these diseases include perturbations in intestinal motility, mucosal inflammation, functional disturbances in intestinal smooth muscle, visceral paresthesia, gastrointestinal hormone imbalances, and dysregulation of the brain-gut axis which manifests itself in symptoms such as abdominal pain, distension, and alterations in defecatory function . Evidence from a considerable number of studies indicates that acupuncture effectively antagonizes the intestinal inflammatory response, promotes GI mucosal epithelial restitution, restores intestinal barrier function, normalizes gut motility and peristalsis, and attenuates chronic visceral hyperalgesia [9-13]. Recently, researchers at the Shanxi Provincial People’s Hospital conducted a human clinical trial to determine the efficacy of acupuncture for the treatment of patients with chronic atrophic gastritis, a condition characterized by chronic inflammation of the stomach and mucosal lining. Following a six-week treatment cycle, the cohort receiving acupuncture demonstrated superior clinical outcomes compared to the group receiving conventional drug therapy (i.e. proton pump inhibitor, antibiotics, anti-inflammatory drugs). According to the results, the symptom severity improvement rate for the group receiving acupuncture was 92.5% compared to 77.4% in the control group. The acupuncture group also demonstrated an 88.7% improvement rate in quantifiable microscopic results compared to 73.6% in the control group. The improvement rate for Helicobacter pylori clearance was 84.9% in the acupuncture group compared to 86.8% in the control group. These results suggest that acupuncture outperforms conventional drug therapy for relieving symptoms associated with chronic atrophic gastritis and inducing biochemical responses that provide protection to the gastric mucosa . In a randomized control trial performed on patients with irritable bowel syndrome (diarrhea-predominant type), acupuncture treatment (“Soothing Gan & Invigorating Pi”) produced significantly greater clinical improvements in the degree and frequency of patient symptoms such as abdominal pain, distension, fecal incontinence, and rectal tenesmus as well as significantly increased quality of life scores compared to the control group who received conventional drug therapy . Numerous other studies have corroborated these findings and concluded that the curative effects of acupuncture may exceed conventional drug therapy in the treatment of adverse symptoms associated with gastrointestinal dysfunction as well as significantly improving overall quality of life [16,17].
A growing body of literature continues to support the efficacy of acupuncture for alleviating adverse gastrointestinal symptoms associated with various GI disorders. Current evidence indicates the potential for acupuncture to treat GI disorders through regulating intestinal motility, reducing visceral sensitivity, antagonizing intestinal inflammation, and modulating neuroendocrine mechanisms involved in the gut-brain axis. While the evidence is compelling and consistent, there remains multiple challenges inherent in the study design of acupuncture research that may impede the production of truly objective analysis. Clinical studies of acupuncture are complicated by the fact that applying stimulation to the same acupoint with different manipulation tactics, frequencies of stimulation, and basal body conditions sometimes yield discordant results. In addition, devising a physiologically inert needling procedure that is indistinguishable from real acupuncture remains a challenge. Therefore, the lack of adequate control groups has made it difficult to properly interpret the data in acupuncture research. Despite these methodological obstacles, the current state of clinical evidence validating the efficacy of acupuncture remains an important consideration in the era of increasing consumer interest in complementary alternative treatment methods. While these studies elucidate the therapeutic benefits of acupuncture unaccompanied by other interventions, it is important to emphasize that achieving optimal GI health requires a multifactorial approach that combines healthy dietary and lifestyle modifications that aim to reduce chronic stress, inflammation, and exposure to environmental toxins. Nevertheless, acupuncture may provide an effective adjunct long-term solution for treating gastrointestinal disorders and its symptomatology.
Bio chemistryUniversity of Texas Medical Branch, USA
Department of Criminal JusticeLiberty University, USA
Department of PsychiatryUniversity of Kentucky, USA
Department of MedicineGally International Biomedical Research & Consulting LLC, USA
Department of Urbanisation and AgriculturalMontreal university, USA
Oral & Maxillofacial PathologyNew York University, USA
Gastroenterology and HepatologyUniversity of Alabama, UK
Department of MedicineUniversities of Bradford, UK
OncologyCirculogene Theranostics, England
Radiation ChemistryNational University of Mexico, USA
Analytical ChemistryWentworth Institute of Technology, USA
Minimally Invasive SurgeryMercer University school of Medicine, USA
Pediatric DentistryUniversity of Athens , Greece
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