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Review Article(ISSN: 2641-1652)

Utilization of Direct Acting Oral Anticoagulants in Patients with Liver Cirrhosis: Is It Safe?

Volume 1 - Issue 2

Saad Qadwai1*, Tayyaba Rehman2 and Zeeshan Solangi3

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    • 1Department of Internal Medicine, Institute of Gaylord Hospital, USA
    • 2Department of MITG, Medical Affairs, Institute Medtronic, USA
    • 3Department of Internal Medicine, Institute Geisinger Medical Center, Danville

    *Corresponding author: Saad Qadwai, Department of Internal Medicine, Institute of Gaylord Hospital, Address: 50 Gaylord Farm Road, Wallingford, CT 06492, USA

Received: May 16, 2018;   Published: May 23, 2018

DOI: 10.32474/CTGH.2018.01.000106

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Abstract

Patients with liver cirrhosis are known to have increased risk bleeding particularly from gastrointestinal tract. However, recent literature has shown that patients with liver cirrhosis are also at increased risk of thrombotic complications. Therefore, it is important to consider anticoagulation in cirrhotic patients. The purpose of this article is to review the epidemiological studies available in scientific literature comparing the risk of bleeding in cirrhotic patients utilizing DOACs vs traditional anticoagulation.

Abbreviations: INR: International Normalized Ratio; VTE: Venous Thromboembolism; DVT: Deep Venous Thrombosis; PE: Pulmonary Embolism; PTT: Partial Thromboplastin Time; LMWH : Low-Molecular-Weight Heparin; NO: Nitric Oxide; PTT: Partial Thromboplastin Time; DOACs: Direct Oral Anticoagulants; AT: Antithrombin; ULN: Upper Limit Of Normal; AUC: Area Under The Plasma Concentration-Time Curve; PD pharmacodynamics; PK: pharmacokinetics

Abstract| Introduction| Methods| Results| Conclusion| References|

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