Rifaximin for Treatment of Small Bowel Bacterial Overgrowth

Dabo Xu and Chung Owyang*

Received: September 03, 2018;   Published: September 06, 2018

DOI: 10.32474/CTGH.2018.01.000115

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Abstract

Small intestinal bacterial overgrowth (SIBO) is often secondary to intestinal dysmotility and several other predisposing conditions. Treatment of SIBO typically includes antibiotics and treatment of underlying etiology. Identification and treatment of the underlying modifiable causes is critical for management of refractory and recurrent SIBO. We report here a case of scleroderma with small bowel dysmotility and bacterial overgrowth, on different occasions the patient failed to respond to Rifaximin. We showed that restoring small bowel motility is critical in maintaining the effectiveness of Rifaximin in the treatment of SIBO. Rifaximin resistance may also develop following prolonged use of antibiotics. Rotation of antibiotic regimen is important to prevent drug resistance.

Keywords: Breath Test; Case Report; Gut Microbiota; Irritable Bowel Syndrome; Nonabsorbable Antibiotics; Octreotide; Prokinetic Agents; Small Intestinal Bacterial Overgrowth

Abbreviations: CI: confidence Interval; FODMAPs: Fermentable Oligo, Di, And Monosaccharides and Polyols; HBT: Hydrogen Breath Test; HE: Hepatic Encephalopathy; IBS: Irritable Bowel Syndrome; SIBO: Small Intestinal Bacterial Overgrowth

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