Potassium-Competitive Acid Blocker: Novel Class of Anti-
Acid Drug

Jaeyong Han MD; Seung Hun Lee MD; Tong Wang MD

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ISSN: 2641-1652

Current Trends in Gastroenterology and Hepatology

Mini Review(ISSN: 2641-1652)

Potassium-Competitive Acid Blocker: Novel Class of Anti- Acid Drug

Volume 2 - Issue 2

Jaeyong Han MD^1,2, Seung Hun Lee MD³ and Tong Wang MD¹*

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- ¹ Department of Cellular and Molecular Physiology, Yale University, New Haven, CT, USA
- ² Department of Internal Medicine, Seoul Bon Clinic, Seoul, Korea
- ³ Department of Internal Medicine, Section of Nephrology, New Haven, USA
*Corresponding author: Tong Wang, Department of Cellular and Molecular Physiology, New Haven, USA

Received:March 09, 2019; Published: March 14, 2019

DOI: 10.32474/CTGH.2018.01.000131

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Abstract

Over the past several decades, great progress has been made on understanding mechanisms of gastric acid secretion for developing new anti-acid drugs. Until now most commonly used anti-acid drugs are histamine-2 receptor antagonists and proton pump inhibitors (PPIs) for patients to control acid related disease. However, several clinical limitations of these drugs had been reported. Recently, a new generation of potassium-competitive acid blockers (P-CABs) were launched for clinical use. It has been shown that these new drugs are more convenient and powerful to treat gastric acid-related diseases. In this article, we briefly reviewed the clinical use of this new anti-acid drug P-CAB.

Keywords:Potassium-competitive Acid Blocker; Potassium channel; H+/K+-ATPase

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