*Corresponding author:Luu Thi My Thuc, Vietnam National Children’s Hospital, Vietnam
Received: February 11, 2019; Published: February 20, 2019
To view the Full Article Peer-reviewed Article PDF
Amino acid (AA) is the main component of proteins. Changes in levels of plasma AA concentration have been mentioned in some cases such as plasma AA concentrations in chronic kidney disease (CKD) patients are low when inflammation status increases  or patients with short bowel syndrome (SBS) undergoing total parenteral nutrition (TPN) have decreasing concentrations of essential amino acids (EAA), increasing rate of malnutrition and complications while for those undergoing part of parenteral nutrition (PN), there was just a decrease in concentrations of two branched chain amino acids, leucin, valine, cysteine, and tyrosine . Autistic children had significant lower plasma levels of leucine, isoleucine, phenylalanine, methionine, cysteine, serine, tyrosine while phosphoserine was significantly raised . In SBS, as intestinal absorption of nutrients is significantly decreased, patients are largely reliant on PN so the concentrations and compositions of AA in PN formula is critical to treatment outcomes. The study was carried out with the
Objective: describe the plasma concentrations of free amino acids in 57 children with SBS and the correlation with clinical symptoms. Method: descriptive cross-sectional study.
Result: High ratio of malnutrition with 96.5% of underweight, 64.9% of stunting and 93% of wasting. All children with SBS had increase of EAA and decrease of non-essential amino acids (NEAA), 38.9% had histidine deficiency, 19.2% had tryptophan deficiency, 14% had arginine deficiency and 12.3% had isoleucine deficiency. AA deficiency is more common in acquired than in functional SBS, in adaptation than in maintenance phase.
Conclusion: High ratio of malnutrition in SBS patients. All children with SBS underwent NEAA deficiencies. Plasma concentrations of free AA largely depended on AA compositions of PN solution.
Keywords: Amino Acid; Short Bowel Syndrome; Children Under 5
Bio chemistryUniversity of Texas Medical Branch, USA
Department of Criminal JusticeLiberty University, USA
Department of PsychiatryUniversity of Kentucky, USA
Department of MedicineGally International Biomedical Research & Consulting LLC, USA
Department of Urbanisation and AgriculturalMontreal university, USA
Oral & Maxillofacial PathologyNew York University, USA
Gastroenterology and HepatologyUniversity of Alabama, UK
Department of MedicineUniversities of Bradford, UK
OncologyCirculogene Theranostics, England
Radiation ChemistryNational University of Mexico, USA
Analytical ChemistryWentworth Institute of Technology, USA
Minimally Invasive SurgeryMercer University school of Medicine, USA
Pediatric DentistryUniversity of Athens , Greece
The annual scholar awards from Lupine Publishers honor a selected number Read More...
We know the financial complexity of Individual read more...
The annual scholar awards from Lupine Publishers honor a selected number read more...