Description of Plasma Concentrations of Free Amino Acids with Some Clinical Symptoms of Patients Under 5 with Short Bowel Syndrome

Luu Thi My Thuc* and Nguyen Thi Hang

Received: February 11, 2019;   Published: February 20, 2019

DOI: 10.32474/CTGH.2018.01.000127

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Abstract

Amino acid (AA) is the main component of proteins. Changes in levels of plasma AA concentration have been mentioned in some cases such as plasma AA concentrations in chronic kidney disease (CKD) patients are low when inflammation status increases [1] or patients with short bowel syndrome (SBS) undergoing total parenteral nutrition (TPN) have decreasing concentrations of essential amino acids (EAA), increasing rate of malnutrition and complications while for those undergoing part of parenteral nutrition (PN), there was just a decrease in concentrations of two branched chain amino acids, leucin, valine, cysteine, and tyrosine [2]. Autistic children had significant lower plasma levels of leucine, isoleucine, phenylalanine, methionine, cysteine, serine, tyrosine while phosphoserine was significantly raised [3]. In SBS, as intestinal absorption of nutrients is significantly decreased, patients are largely reliant on PN so the concentrations and compositions of AA in PN formula is critical to treatment outcomes. The study was carried out with the

Objective: describe the plasma concentrations of free amino acids in 57 children with SBS and the correlation with clinical symptoms. Method: descriptive cross-sectional study.

Result: High ratio of malnutrition with 96.5% of underweight, 64.9% of stunting and 93% of wasting. All children with SBS had increase of EAA and decrease of non-essential amino acids (NEAA), 38.9% had histidine deficiency, 19.2% had tryptophan deficiency, 14% had arginine deficiency and 12.3% had isoleucine deficiency. AA deficiency is more common in acquired than in functional SBS, in adaptation than in maintenance phase.

Conclusion: High ratio of malnutrition in SBS patients. All children with SBS underwent NEAA deficiencies. Plasma concentrations of free AA largely depended on AA compositions of PN solution.

Keywords: Amino Acid; Short Bowel Syndrome; Children Under 5

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