Chemically-Induced Peptic Ulcer: Gastroprotective Effects of Peach Fruit

Volume 1 - Issue 2

Qaiser Jabeen*, Sidra Arif and Fayyaz Anjum

Received: June 12, 2018;   Published: June 18, 2018

DOI: 10.32474/CTGH.2018.01.000107

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Abstract

Background: Peptic ulcer, an inflammatory breach in the gastric and duodenal mucosa, is caused by hyper secretion of gastric acid and defective mucosal protective elements, affecting approximately 4 million people each year. The currently available antiulcer drugs are reported to have severe side effects. Hence, there is a need to develop more effective and less toxic alternative therapeutic agents from natural sources. The current study was conducted to investigate the therapeutic potential of Prunus persica Linn. Batsch fruit (Peach) against chemically-induced gastric and duodenal ulcers.

Material and Methodology: 70% aqueous methanolic crude extract of Prunus persica (Pp.Cr) was prepared. Gastroprotective effects were evaluated by oral administration of Pp.Cr at the doses of 100, 300, 500 mg/kg for ten days. Normal control and intoxicated groups were treated with distilled water. Bismuth subsalicylate (88 mg/kg) was administered to the standard control group. On 10th day, all animals were intoxicated with ethanol (5 ml/kg) except normal control group, and one hour after intoxication, all animals were sacrificed, stomach isolated; and pH and acidity of gastric contents, ulcer index and percentage protection were calculated. One stomach from each group was analyzed histo pathologically. Duodenal protective effects were assessed by administering Pp.Cr (100, 300, 500 mg/kg) for fourteen days. The standard control group was treated with cimetidine (100 mg/kg). On 14th day, cysteamine (600 mg/kg) was administered in two divided doses at an interval of four hours to experimental animals to induce duodenal ulcer. All animals were dissected out 48 hours after the administration of first dose of cysteamine. Duodenum was isolated and analyzed for severity score. Histopathological examination of one duodenum from each group was performed.

Results: In gastric ulcer model, Pp.Cr was found to increase pH and decrease the total acidity of gastric contents, and decrease the ulcer index, in dose-dependent manner at the doses of 100, 300 and 500 mg/kg. In duodenal ulcer model, Pp.Cr was observed to decrease the severity score and ulcer index, again in dose-dependent manner.

Conclusion: The results of current study demonstrate the gastric and duodenal protective effects of the crude extract of Prunus persica (Pp.Cr), corroborating their folkloric use in the prevention and treatment of peptic ulcer.

Keywords: Ulcer; Duodenum; Prunus persica; Gastroprotective; Gastric Ph; Ulcer Index

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