The Effect of Glibenclamide Administration on Gastrin Release in Diabetic Patients Volume 3 - Issue 2

George C Nikou*, George Evangelou, Vera Nikou and Efrosyni Kitsiou

• Section of Neuroendocrine Tumors, 3rd Department of Internal Medicine, National and Kapodistrian University of Athens, Greece

Received:NFebruary 22, 2021;   Published: March 4, 2021

Corresponding author: George C Nikou, Section of Neuroendocrine Tumors, 3rd Department of Internal Medicine, National and Kapodistrian University of Athens, “Sotiria” Hospital, Athens, Greece

DOI: 10.32474/ADO.2021.03.000159

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Abstract

The effects of sulfonylureas on gastrointestinal function in man is not yet quite clear. The aim of this study was to investigate the effect of oral administration of glibenclamide on gastrin release in patients with non-insulin dependent diabetes mellitus. Twelve non-insulin dependent diabetic patients (six men, six women, median age 57 years, range 46-63 years) were studied. Glibenclamide or placebo were given on different days and in a random order 10 minutes before a standard meal (73.6 g corned beef + 5ml olive oil + 60g bread). Blood samples for the determination of gastrin, glucose and C-peptide in serum, before (-15 and 0 minutes) and 30, 60 , 90 , 120 and 180 minutes after the standard meal, were obtained. Initial mean values of gastrin in serum did not differ significantly between the two meals. As expected gastrin levels increased significantly after taking the meals. However, no significant differences concerning mean gastrin concentrations between the two meals were noted at all time intervals studied, although there was a trend for the glibenclamide-preceded meal to exert lower gastrin values, especially at 60 minutes (p: 0,06). Mean serum glucose levels were, as anticipated, significantly lower after the glibenclamide-meal. Similarly, serum C-peptide concentrations were higher after this meal. It is concluded that acute glibenclamide oral administration does not influence post-stimulatory 3 gastrin levels in non-insulin dependent diabetic patients. Thus, in the clinical situation, sulfonylurea administration does not seem to interfere with gastrin release.

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