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Review Article(ISSN: 2638-5910)

Oleuropein as a novel anti-diabetic nutraceutical. An overview

Volume 1 - Issue 3

Giuseppe Annunziata1*, Maria Maisto1, Connie Schisano1, Luigi Barrea2, Roberto Ciampaglia1, Viviana Narciso1, Gian Carlo Tenore1 and Ettore Novellino1

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    • 1Department of Pharmacy, University of Naples Federico II, Naples, Italy
    • 2Department of Clinical Medicine and Surgery, Federico II University Medical School of Naples, Italy

    *Corresponding author: Giuseppe Annunziata, Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131, Naples, Italy

Received: August 25, 2018;   Published: August 28, 2018

DOI: 10.32474/ADO.2018.01.000113

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Abstract

Among the cardiometabolic diseases, type 2 diabetes mellitus (T2DM) is one of the most diffused worldwide. Pharmacological treatments commonly used present several side effects, and this is driving people to search natural approaches. Olea europaea is currently investigated for its anti-diabetic potential. In particular, oleuropein (OLE), its main bioactive compound, have been demonstrated to exert interesting activities in management of T2DM, including hypoglycemic and antioxidant activities. The purpose of this manuscript is to review the available scientific evidence evaluating the role of OLE in managing T2DM.

Keywords: Oleuropein; Type 2 Diabetes; Glucose Homeostasis; Oxidative Stress; Antioxidant

Abbreviations: T2DM: Type 2 Diabetes Mellitus; CVD: Cardiovascular Disease; AMPK: Amp- Activated Protein Kinase; OLE: Oleuropein; SGLT1: Sodium-Dependent Glucose Transporter; EFSA: European Food Safety Authority; IGT: Impaired Glucose Tolerance: TSOD: Tsumura Suzuki Obese Diabetes; GLUT: Glucose Transporter; ROS: Reactive Oxygen Species; RNS: Reactive Nitrogen Species; MDA: Malondialdehyde; HT: Hydroxytyrosol

Abstract| Introduction| Oleuropein: from chemistry to biology| Anti-diabetic effects of oleuropein| Conclusion and future perspectives| References|

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