Comparative Study of Degree of Low Grade Chronic Inflammatory Status in Freshly Diagnosed Type 1 with Type 2 Diabetic Patients

Volume 1 - Issue 5

Shamim Shaikh Mohiuddin¹* and Poornima Manjrekar²

Received: November 15, 2018;   Published: November 21, 2018

DOI: 10.32474/ADO.2018.01.000121

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Abstract

Low grade inflammatory condition which is predominately cytokine-mediated is observed to be closely involved in the pathogenesis of type 2 diabetes as well as role this inflammatory condition cannot be ruled out in involvement in pathogenesis of type 1 diabetes. Since maximum world populations are at high risk of developing diabetes, we tested this hypothesis by estimating circulating acute phase proteins in freshly diagnosed type 2 (T-2) as well as type1(T-1) diabetic patients.

The acute phase proteins, α1- antitrypsin, α1- acid glycoprotein, ceruloplasmin and fibrinogen were estimated in the plasma in freshly diagnosed twenty-five T-2 cases and twelve T-1cases. Thirty normal controls to match the age and sex of the test groups were also studied. The levels of these proteins were correlated with their BMI and random plasma glucose values.

In comparison with the controls, the values of all the four proteins studied were significantly elevated in the T-2 patients (p<00001). In case of T-1 patient level of ceruloplasmin and fibrinogen are significantly elevated. Interestingly, no correlation was found with BMI or the degree of hyperglycemia in either of the types. A low-grade inflammatory process is definitely implicated in the pathogenesis of type 2 diabetes. Same can be ruled out in type-1 diabetic patients also. The comparative study of the states of all these inflammatory markers in case of T-2 and T-1 patients is of interest in this present study.

Keywords: Acute Phase Proteins; Low Grade Chronic Inflammation; Type 1 Diabetes Mellitus; Type 2 Diabetes Mellitus

Abbreviations: CRP: C-reactive Proteins; IL-1: Interleukin-1; IL-6: Interleukin-6; TNF: Tumor Necrosis Factor; RBS: Random Blood Sugar; LDL: Low Density Lipoprotein; KD: Kilo Dalton

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