Salmonella is one of a major foodborne pathogen worldwide that table egg as one of the vehicles for its transmission. Across
sectional study was conducted from November 2018 to April 2019 in Bahir Dar Town to identify Salmonella isolates from table egg
and to determine their antimicrobial resistance profile. A total of 157 egg samples were collected by systematic random sampling
technique and processed for isolation of Salmonella by conventional bacteriological methods. Antimicrobial sensitivity test was
performed for 10 selected antibiotic discs by disc diffusion. The overall level of Salmonella prevalence in current study was 2.23 %.
Prevalence of salmonella based on site and part of eggs were 3.85% from the open market and 1.28% from the poultry farm. About
3.80% of Salmonella was observed from internal contents of farm eggs. Isolation rate of Salmonella between sample sites and egg
parts were not statistically significant (p = 0.69) and (p=0.702) respectively. All Salmonella isolates were susceptible to gentamycin;
however, all of them were resistant to ampicillin, tetracycline and cephalothin. All isolates were developing multiple drug resistance.
Confirmation of Salmonella from egg indicates hygiene protocols should be applied from farm to mouth to prevent the infection
of human beings by Salmonella. Even though the isolation rate was low in current finding, isolates were developing multidrug
resistance. Drug resistance is mobile; the genes for resistance traits can be transferred among bacteria of different taxonomic and
ecological groups by means of transduction, conjugation, and transformation. Therefore, proper egg handling, strict biosecurity
measures and rational antimicrobial usage should be practiced.