Effect of Periparturient Intranasal Vaccination on Post
Parturient Health Parameters in Holstein Cows
Volume 3 - Issue 4
Cortese VS1*, Pinedo PJ2, Manriquez D2, Velasquez-Munoz A2, Solano G2, Short TH3, Cleale R3, Edwards G4,
Montgomery T5, Pedraza JR3 and Bachtell R6
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- 1Zoetis INC, 746 Veechdale Road, USA
- 2Department of Animal Sciences, Colorado State University, USA
- 3Zoetis INC, Parsippany, USA
- 4sup>1070 Kenilworth Ave. Napoleon, USA
- 5Maple Row Dairy, Saranac, USA
- 6Bachtell Veterinary Service, Mercersburg, USA
*Corresponding author:
Victor Cortese, Zoetis INC, 746 Veechdale Road, Simpsonville, KY 40067, USA
Received: February 18, 2020; Published: February 27, 2020
DOI: 10.32474/CDVS.2020.03.000167
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Abstract
The objective of this study was to evaluate the effect on health and reproductive performance of vaccinating Holstein cows
with an intranasal modified live viral vaccine (INV) during the peri-parturient period. Two conventional, free stall dairies and
one organic certified dairy were enrolled in the study. In the two conventional dairies cows were vaccinated 18-24 days prior to
expected parturition. In the third herd cows were vaccinated 18-24 days prior to expected calving date, within twelve hours after
parturition or at both time points. Cattle were blocked based on parity group and expected calving date and randomized to the
experimental treatments (vaccination and control) within blocks. Health and reproductive outcomes were monitored and compared
to matched, randomly assigned control cows. Results from the first two dairies were used to determine power calculations for
the final study in herd 3. The greatest effects of vaccination were decreases in total cows removed from the herd throughout the
lactation, decreased presentation of retained fetal membranes, and lower incidences of pneumonia and mastitis. Overall, a greater
impact was determined with two doses and, if one dose was administered, the results tended to favor administration at calving.
Keywords: postpartum health, postpartum immune suppression, calving stress, intranasal vaccination, immunomodulation
Abbreviations: RFM: Retained Fetal Membranes; BRSV: Bovine Respiratory Syncytial Virus; CON: Non-Vaccinated Negative
Control; AI: Artificial Insemination
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