An 89 yr Caucasian male resident of a long-term care facility
with past medical history of hypertension, type 2 diabetes mellitus,
and coronary artery disease developed a painless skin lesion
on the right side of his face. The lesion grew rapidly into a large
lesion. Initial biopsy resulted inconclusive and required further
pathological analysis. Further study of the specimen revealed the
presence of hidradenocarcinoma. The patient underwent surgical
excision and subsequent skin grafting due to the size of the lesion.
He had recurrence of the tumor, requiring multiple additional
surgical procedures and radiation therapy. Despite aggressive
treatment, the tumor continued to grow, invading into surrounding
tissues including the orbit and oral cavity. The patient decided to
discontinue treatments and opted for comfort care with Hospice.
He subsequently passed away at the long-term care facility (Figures
1-16).
Figure 1: Disease progression shown in the photos.
Hidradenocarcinoma is a rare form of malignancy associated
with abnormal growth of sweat glands. Typically occurring in people
aged 30-60, it can occur anywhere on the body, but usually seen
on the head and neck area. It generally begins as a painless, solitary
lesion that tends to have slow growth. Hidradenocarcinoma does
have the ability to metastasize to local tissues or to distant body
parts. At this time, the cause of hidradenocarcinoma remains unknown.
Diagnosis is made via obtaining a skin biopsy and pathological
evaluation, which can be challenging. Hidradenocarcinoma can
resemble benign lesions on pathological exam. Treatment includes
surgery to remove the tumor, as well as radiation and/or chemotherapy.
Prognosis is best if found early, otherwise it is poor.