Thioglycosides and Cancer Prevention

Anubhuti Sharma*, Ashok Kumar, Arun Kumar, HS Meena, Prashant Yadav, Priti Gupta, Vijaya Laxmi Tripathi, Aadityendra K Sharma and PK Rai

Received: March 26, 2018;   Published: April 06, 2018

DOI: 10.32474/AOICS.2018.02.000141

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Abstract

Plant food contains numerous nutritional & anti-nutritional compounds, which prevents various non-communicable diseases such as cancer. This paper gives an overview of the cancer preventive effect of brassica. In recent years, considerable attention has been paid to cancer protective role of Brassica through major secondary metabolites i.e. glucosinolates. Glucosinolates and their breakdown products have been widely studied for their biological effect on human and animal nutrition. These are responsible for the secretion of detoxifying enzymes that remove carcinogens from the organism. Furthermore, they activate proteins and II phase detoxifying enzymes. They act as a major defence system to plants and humans. However breakdown products of glucosinolates e.g. isothiocyanate and indole regulates cancer cell development by regulating target enzymes, which are involved in controlling apoptosis and blocking of the cell cycle. The present paper reviews the available literature on glucosinolates, their biosynthesis, hydrolysis, their health promoting beneficial effects and possible role in imparting defence against diseases especially cancer.

Keywords: Glucosinolates; Brassica; Isothiocyanates; Phase II enzymes

Abstract| Introduction Biosynthesis| Diversity| Hydrolysis| Conclusion| Acknowledgement| References|