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ISSN: 2637-4609

Archives of Organic and Inorganic Chemical Sciences

Research ArticleOpen Access

Synthesis and Antitubercular Acitivity of New Imidazo [2,1-B] [1,3,4] Thiadiazole-Phenothiazine Derivatives

Volume 3 - Issue 4

Sunil Makwane1 and Rajiv Dua2*

  • Author Information Open or Close
    • 1Department of Chemistry, Dr. Harisingh Gour University, India
    • 2Department of Chemistry, Government of Madhya Pradesh, India

    *Corresponding author: Rajiv Dua, Department of Chemistry, State Forensic Science Laboratory, Department of Home (Police), Government of Madhya Pradesh, India

Received: August 21, 2018;   Published: August 29, 2018

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Abstract

New series of 10-(2-Styryl-5,6-dihydro-imidazo[2,1-b] [1,3,4] thiadiazole-6-yl)-10H-phenothiazine were synthesized by cyclisation of various carboxylic acid with thiosemicarbazide in presence of sulphuric acid was to get compound 1. Another way phenothiazine treated with chloroacetyl chloride yielded compound 2. Further cyclisation of compound 1 and 2 followed by refluxation about 18 hrs to get the final products 3 and 3a-3i of the series. The structures of compounds were confirmed by IR, 1H-NMR, 13C NMR and mass spectroscopy and by chemical analysis. All the final synthesized compounds 3 and 3a-3i were screened for their antitubercular activity screened against M. tuberculosis H37 Rv.

Keywords: Thiadiazole; Phenothiazine; Thiadiazole; Antitubercular Activity

Graphical Abstract
Scheme 1.

Abstract| Introduction| Materials and Methods| Results and Discussion| Antitubercular activity| Conclusion| Acknowledgement| References|

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