Synthesis and Antitubercular Acitivity of New Imidazo
[2,1-B] [1,3,4] Thiadiazole-Phenothiazine Derivatives
Volume 3 - Issue 4
Sunil Makwane1 and Rajiv Dua2*
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- 1Department of Chemistry, Dr. Harisingh Gour University, India
- 2Department of Chemistry, Government of Madhya Pradesh, India
*Corresponding author:
Rajiv Dua, Department of Chemistry, State Forensic Science Laboratory, Department of Home (Police),
Government of Madhya Pradesh, India
Received: August 21, 2018; Published: August 29, 2018
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Abstract
New series of 10-(2-Styryl-5,6-dihydro-imidazo[2,1-b] [1,3,4] thiadiazole-6-yl)-10H-phenothiazine were synthesized by
cyclisation of various carboxylic acid with thiosemicarbazide in presence of sulphuric acid was to get compound 1. Another way
phenothiazine treated with chloroacetyl chloride yielded compound 2. Further cyclisation of compound 1 and 2 followed by
refluxation about 18 hrs to get the final products 3 and 3a-3i of the series. The structures of compounds were confirmed by IR,
1H-NMR, 13C NMR and mass spectroscopy and by chemical analysis. All the final synthesized compounds 3 and 3a-3i were screened
for their antitubercular activity screened against M. tuberculosis H37 Rv.
Keywords: Thiadiazole; Phenothiazine; Thiadiazole; Antitubercular Activity
Graphical Abstract
Scheme 1.
Abstract|
Introduction|
Materials and Methods|
Results and Discussion|
Antitubercular activity|
Conclusion|
Acknowledgement|
References|