The fast emerging of superbugs’ resistance against common commercial antibiotics has been timely challenges and temporarily
assuaging outbreak concerns in modern medicine. But coincidentally, there has been a significant retraction on new drugs design
as effective antimicrobial medicines by the major pharmaceutical companies with the coinciding escalation in global nosocomial
infection. Originally, antibiotics were described as ‘‘produced by microorganisms and which possess the property of inhibiting the
growth and even of destroying other microorganisms” . Now a day’s most commercially antibiotics however, are obtained from
other sources than microbiological processes with many clinically ‘‘antibiotic drugs’’ being either synthetic or semi-synthetic ones.
Some of these new synthetic antibiotics are characterized by the presence of specific metals to function properly as an integral
part of the structure and function as defined in the medicine SAR’s interpretation . Therefore, the removal of essential metal
ions from these medicines might results in the deactivation and/or change in the structure of the mas observed on bacitracin,
bleomycin (BLM), streptonigrin (SN), and albomycin . In addition, the presence of metalsin some antibiotics engender bacteria
with biochemical consequences but do not significantly affect the structure of the drug, such as occur in metallated tetracycline’s
(TCs), aureolic acids, and quinolones. Similar to the case of ‘‘metallo proteins,’’ these families of antibiotics are thus dubbed ‘‘metallo
antibiotics’’ and are under scrutiny in our research with the aim of improve the reduced scope of non--lactamase bactericidal/
bacterio static agents.
Keywords: To that, we are occupied in the chemical synthesis of artificial chelators and metal complexes obtained this time between
dipicolonic acid (DPA), 2-methylsalycilate (MeSal), and methavanadate (V=O), for in vitro antibacterial screening and results compared
with those obtained using commercially antibiotics. Here we report on the microbiology results performed with a vanadium VIV
complex (vanadibacter) that is probing to have moderate to excellent bactericidal effects on a broad scope of gram-positive/gramnegative
strains, especially against family of pathogenic superbugs which are considered the leading cause of nosocomial infections
throughout the world and so called ESKAPE group. To that in vitro tests were carried out on Enterococcus faecalis, Staphylococcus
aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter aerogenes, with those cells
grown under iron uptake limitations .