Coumarin and Coumarin-related compounds are major source of interest for many of medicinal chemist to explore its various
pharmacological potentials especially bis-coumarin for their anticoagulant activity. A number of reports have appeared in the
literature on the enhancement of bioactivity of bis heterocyclic compounds over simple heterocyclic compounds. Biscoumarin are
very well known and possess better biological activities like anticoagulant, anti oxidant, antimicrobial activity, anti cancerous and
analgesic activity than the parent nuclei. Hence, realizing the importance of biscoumarin, we thought to summarize the synthesis of
bis-coumarins under solvent-free conditions in this review.