Multi-Component Synthesis of Novel Diazoles: their Characterization and Biological Evaluation

Volume 1 - Issue 2

Shad HA¹*, Hussain A¹, Shahzad K¹, Abeeha¹, Hussain G², Khan ZI³, Ahmad K³, Alam MM¹ and Ilyas M¹

Received: January 13, 2018;   Published: January 29, 2018

DOI: 10.32474/AOICS.2018.01.000107

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Abstract

A new series of imidazoles were synthesized by multiple component system through condensation reaction of benzil, substituted aldehydes, substituted anilines and ammonium acetate. Glacial acetic acid was used as solvent. The bonding behavior and structure of the prepared compounds have been deduced from infra red spectroscopy, conduction method, and CHN analysis data. The synthesized imidazoles have been examined for in-vitro antibacterial properties. The results of these studies have shown that all compounds exhibited fair to major antibacterial activity against one or more bacterial strains.

Keywords: Imidazole; Biological Activity; Benzil; Aldehydes; Amines

Abstract| Introduction| Materials and Methods| Results and Discussions| Conclusion| Acknowledgement| References|