Liquid Chromatography-Mass Spectrometry
and Its Applications: A Brief Review
Volume 1 - Issue 1
Nikalje Anna Pratima* and Ramesh Gadikar
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- Department of Pharmaceutical Chemistry, YB Chavan College of Pharmacy, India
*Corresponding author:
Nikalje Anna Pratima, Department of Pharmaceutical Chemistry, YB Chavan College of Pharmacy, Dr. Rafiq
Zakaria Campus, Aurangabad 431001, Maharashtra, India
Received: January 06, 2018; Published: January 24, 2018
DOI: 10.32474/AOICS.2018.01.000103
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Abstract
The Liquid Chromatography-Mass Spectrometry (LC-MS) is a powerful analytical technique with very high sensitivity and
specificity. LC-MS is combination of Liquid Chromatography (LC) and Mass Spectrometry (MS). With the Liquid Chromatography
(LC) the separation of components can be done and then the sample eluents from LC are transferred into Mass Spectrometry (MS)
where the detection, identification and determination of masses of components can be done in presence of other components.
LC-MS is used in determination, of pharmaceutical drug substances, intermediates and its related compounds for quantitative and
qualitative purpose. LC-MS is used most significantly in in-vitro dissolution, bio-equivalence, bioavailability and metabolite studies.
Also LC-MS is used in basic research, agrochemical, forensic laboratories and food industries .In this article principle of LC-MS,
instrumentation and its applications are briefly discussed.
Keywords: Liquid chromatography (LC); Mass spectrometry (MS); High Performance Liquid Chromatography (HPLC); Liquid
Chromatography-Mass Spectrometry (LC-MS)
Abstract|
Introduction|
Instrumentation|
Detectors|
Applications|
Conclusion|
References|