Myocardial bridge in Resting state does not Induce Myocardial Ischemia Confirmed by Fractional flow Reserve Volume 3 - Issue 5

Fu Qiang¹, Zeng Youfa¹, Miao Zhilin¹, Guan Ruming¹, Zhao Linlin¹, Su Hao¹, Lv He¹, Guo Xinjin² and Hou Aijie¹

• ¹Department of Cardiology, The People’s Hospital of China Medical University/The People’s Hospital of Liao Ning Province, Shen Yang, Liao Ning, China
• ²Department of Research and Development, Hong Kong Biotechnology and Development Institute, Hong Kong SAR, China

Received:June 3, 2020;   Published:June 24, 2021

Corresponding author: Guo Xinjin, Department of Research and Development, Hong Kong Biotechnology and Development Institute, Hong Kong SAR, China

DOI: 10.32474/ACR.2021.03.000171

 

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Abstract

Objective: To investigate whether myocardial bridge (MB) in resting state leads to myocardial ischemia by measuring coronary fractional flow reserve (FFR) and analyze the influence of the most severe stenosis degree(MSSD) and the length of mural coronary artery (MCA) on the decline degree of FFR.

Materials and methods: 39 patients with MB in left anterior descending coronary artery confirmed by coronary computed tomography angioplasty were recruited. Hyperemic proximal FFR (FFRp) and distal FFR(FFRd) of MCA were measured by pressuretemperature sensor guidewire, and then the decline degree of FFR(FFRp-FFRd, FFRp-d) were calculated. QCA software was used to determine MSSD and the length of MCA (MCAL).By comparing FFRp with FFRd, the effect of MB on FFR was analyzed. FFR=0.8(i.e. FFRp-d =0.2 (1-0.8)) was taken as the threshold value of myocardial ischemia to explore the correlation between MB and myocardial ischemia; In addition, we further observed the influence of MCAL and MSSD on FFRp-d.

Results: FFRd is significantly lower than FFRp (P < 0.01).However, FFRp-d was significantly lower than 0.20 (P < 0.01).Another aspect deserves due attention is that there was no correlation between FFRp-d and MCAL(P > 0.05) and MSSD (P > 0.05). Conclusion: Although MB causes a significant decrease in FFR, no ischemia is induced. The degree of FFR decline is independent of both MCAL and MSSD;

Keywords:Myocardial bridge; Mural coronary artery; Fractional flow reserve

Abstract| Introduction| Material and Methods| Statistical Analysis| FFR decline is independent of MCAL and MSSD| The longer the MCAL is,the more severe MSSD is| Conclusion| References|