Thrombosis in Iron Deficiency and Iron Deficiency Anemia: A Review of our Cases and the Relevant Literature

Volume 2 - Issue 3

Ceren Kılcı¹, Lale Olcay¹*, Taner Sezer¹, I Zafer Ecevit¹, Murat Özkan² and Birgül Varan¹

Received: July 18, 2018;   Published: July 30, 2018

DOI: 10.32474/OAJOM.2018.02.000139

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Abstract

We evaluated our thrombosis cases for iron deficiency (ID) or iron deficiency anemia (IDA) retrospectively and reviewed the literature. We established that iron parameters were studied in 17 of 64 patients with thrombosis and 2 of 17 patients had IDA. Case 1 (age 16, female) had occlusions in sigmoid and transverse sinuses and right jugular vein and case 2 (age 15, male) had infarct in right cerebellar hemisphere. While case 1 additionally had mastoiditis, high Factor (F) VIII and PAI 4G/5G polymorphism, case 2 who underwent a recent aortic graft insertion operation for aortic aneurysm had high serum lipids, lipoprotein a, homocysteine, FVIII, d-dimer. Of 54 thrombosis cases with ID/IDA in the literature, cerebral thrombosis made up of 70.4% of all the cases, venous cerebral occlusions comprising 100% and 66% of venous thrombosis in children and adults respectively. Our findings show that ID/ IDA may be a risk factor for thrombosis, especially in cerebral veins.

Keywords: Iron deficiency anemia; Coagulation; Thrombosis; Thromboembolism

Abstract| Introduction| Materials and Methods| Results| Case 1 (O.E.)| Case 2 (EA)| Literature Review| Discussion| Conclusion| References|