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ISSN: 2638-5945

Open Access Journal of Oncology and Medicine

Research Article(ISSN: 2638-5945)

The Anti-Cancer Properties of Cannabidiol and Δ-9Tetrahydrocannabinol in Haematological Malignancies In Vitro Volume 4 - Issue 5

Bethan Hamill1, Saffran Pick1 and Lisa Lee-Jones1*

  • 1Life Sciences Department, Manchester Metropolitan University, Manchester, United Kingdom

Received:August 19, 2021   Published: September 2, 2021

Corresponding author: Dr Lisa Lee-Jones, Department of Life Sciences, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M1 5GD, United Kingdom

DOI: 10.32474/OAJOM.2021.04.000200

 

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Abstract

Background: Haematological malignancies are the fifth commonest cancer in the UK, with an average 5-year survival rate of 70.5%. Drug resistance and recurrence affect many patients with blood cancers. The anticancer properties of Cannabis constituents, Delta-9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD), in a variety of neoplastic cell lines, including those of the breast, skin, lung, and prostate, have been previously reported. This research investigated the cytostaticity and cytotoxicity of CBD and THC, synergism between CBD and THC, and chemosensitisation with Hydroxyurea (HU) in two haematological malignancy cell lines, Jurkat and U937.

Methods: U937 and Jurkat were incubated with various concentrations and combinations of CBD, THC, and HU for 24, 48, and 72 hours, then their effects on cell viability and proliferation were evaluated.

Results: Both CBD and THC reduced viability and proliferation in Jurkat and U937 in a time- and dose-dependent manner. CBD and THC demonstrated synergism in both cell lines. Combinations of cannabinoids and HU resulted in greater growth inhibition and cytotoxicity in both cell lines, than when any agent was used individually.

Conclusion: These findings suggest CBD and THC may be useful for treating haematological malignancies and warrant further in vitro studies.

Abstract| Background| Methods| Results| Discussion| Conclusion| Competing Interests| Additional Information| Acknowledgements| Author Contributions| Ethics Approval| Not applicable| Data Availability| Competing Interest| Funding Information| Cell Line Authentication| References|

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