Subjection between Breast Cancer and Body Mass Index, the Role of L-Carnitine in Prediction and Outcomes of the Disease

Volume 1 - Issue 1

Hojouj Mohammad IM*¹, I.N Bondarenko¹, V.F Zavizion¹,Y.N Bondarenko,¹Hojouj T.V¹ ,Salviova N¹ and YA Shevchenko¹

Received: January 18, 2018;   Published: January 23, 2018

DOI: 10.32474/OAJOM.2018.01.000103

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF

Abstract

Increasing the effectiveness of antitumor therapy in breast cancer patients who take L-carnitine during preoperative systemic antitumor therapy compared with patients receiving standard neoadjuvant systemic antitumor therapy served as a prerequisite for studying possible antitumor mechanisms of L-carnitine. The positive effect of L-carnitine is due to the transfer of palm-n-LC through the inner membrane into the mitochondrial matrix, which promotes the formation of a significant number of ATP molecules. It has also been shown that L-carnitine can have a double protective effect, enhancing the energy dynamics of the cell and inhibiting the hyperexcitability of the cell membrane, that making it an ideal nutrient for the prevention and treatment of cancer. This article summarizes the results of epidemiological and clinical studies of the use of L-carnitine in the treatment of breast cancer

Keywords: Body mass index (BMI); Breast cancer (BC); Obesity; Overall survival; L carnitine

Abstract| Introduction| Conclusion| References|