email   Email Us: info@lupinepublishers.com phone   Call Us: +1 (914) 407-6109   57 West 57th Street, 3rd floor, New York - NY 10019, USA

Lupine Publishers Group

Lupine Publishers

ISSN: 2638-5945

Open Access Journal of Oncology and Medicine

Mini Review(ISSN: 2638-5945)

Receptor Status Accuracy in Breast Cancer: Core Biopsy or Excision? A Mini Review

Volume 3 - Issue 5

Mohammed J Alyousef*, Mohammed M Hajla and Maha Abdel Hadi

  • Author Information Open or Close
    • Departments of Pathology and Surgery, Imam Abdulrahman Bin Faisal University, Saudi Arabia

    *Corresponding author: Mohammed J Alyousef, Departments of Pathology and Surgery,Imam Abdulrahman Bin Faisal University, Saudi Arabia

Received: August 11, 2020;   Published: August 20, 2020

DOI: 10.32474/OAJOM.2020.03.000175

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF

Abstract

Aim

With the advent of minimally invasive surgical techniques core needle biopsy (CNB) has emerged as an accurate method of obtaining representative tissue providing both prognostic and diagnostic valuable information the management of breast cancer. This review aims to compare the precision and limitations in the reporting of CNB and excisional biopsies. (EB)

Materials and Methods: All patients diagnosed with breast cancer were reviewed. Review of the histological data was the essence of this study. Only patients whose receptors were tested in both core and excisions were included. The hormonal status of estrogen receptors (ER), progesterone receptors (PgR) and Her2 were evaluated immunohistochemically. Equivocal HER2 status was reassessed using Fluorescence in situ hybridization (FISH) test.

Results: The total number of patients diagnosed with breast cancer was 112. In 36 (32.1%) patients complete synchronized immunohistological testing for both CNB and EB was executed and compared. The concordance rate observed in was as follows:ER was matched in 27 (75%), PgR in 22 (61.1%) Her2 in 34(94%).The calculated concordance rate was 86%, 80%, 94% for ER PgR and Her2 respectively.

Conclusion: CNB has proven a valuable and an adequate minimally invasive method for obtaining an accurate representative tissue. The reliability in obtaining HER2 status can be precisely determined however, ER and PgR should be interpreted with caution.

Keywords: Core Needle Biopsy; Excision Biopsy; Concordance; Breast Cancer

Abstract| Introduction| Materials and Methods| Results| Conclusions| Limitation of the Study| Conflict of Interest| References|

Close

Online Submission System

Drag and drop files here

or

Browse Files
( For multiple files submission, zip them in a single file to submit. For file zipping software Download )