Prostate Cell Lines Volume 5 - Issue 2

Abdulghani A Naeem¹, Saud A Abdulsamad¹, Asmaa Al Bayati¹, Jiachen Zhang¹, Mohammed I Malki², Hongwen Ma³, and Youqiang Ke¹*

• ¹Department of Molecular & Clinical Cancer Medicine, Liverpool University, Liverpool, United Kingdom
• ²College of Medicine, Qatar University, Qata
• ³Department of Urology, Institute of Urology, West China Hospital, Sichuan University, China

Received: February 11, 2022   Published: February 25, 2022

Corresponding author: Youqiang Ke, Professor, Department of Molecular & Clinical Cancer Medicine, Liverpool University, L69 3GA, United Kingdom

DOI: 10.32474/OAJOM.2022.05.000208

 

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Abstract

When it comes to studying biological processes, cell lines are typically utilized in lieu of original cell samples. Like in the studies for other cancer types, researchers in prostate cancer can be constrained in their ability to discover new treatments because of a lack of cell lines to investigate pre-clinical status. There are various forms of prostate cancer cell lines that are reviewed in this work. A cautionary note is in need since cell lines may not always correctly mimic the original cells. Cancerous cells are immortal and using cell lines produced from cancer cells as a model to better understand cancer and to develop novel therapies are common in research. Apart from the prostate cancer cells, we also reviewed two cell lines PNT2 and RWPE-1 which were established from non-neoplastic male prostatic epithelial cells.

Abstract| Introduction| PNT-2 Cells| RWPE1 Cells| CWR-R1ca Prostate Cancer Cell Line| LNCaP Cell Line and Its Derivatives| 22Rv-1 Cells| Du-145 Cells| PC-3 Cell and PC-3M Cells| General Comments for the Cells| Conclusion| Acknowledgements| References|