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Lupine Publishers

ISSN: 2638-5945

Open Access Journal of Oncology and Medicine

Mini Review(ISSN: 2638-5945)

Permissiveness Paradox in Cell Cycle Progression Towards Genome Instability and Malignant Transformation

Volume 2 - Issue 2

Lawrence M Agius*

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    • Department Of Pathology, Mater Dei Hospital, Tal-Qroqq, University Of Malta Medical School, Msida, Malta Europe

    *Corresponding author: Lawrence M Agius, Department Of Pathology, Mater Dei Hospital, Tal-Qroqq, University Of Malta Medical School, Msida, Malta Europe

Received: June 14, 2018;   Published: June 19, 2018

DOI: 10.32474/OAJOM.2018.02.000133

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Abstract

Dimensional representation of events actively executing the cell cycle dynamics of progression in carcinogenesis allow for a paradoxical emergence of highly permissive elements in the establishment of the mitotic spindle and the separation of chromatids. In such terms, ongoing processes of dissolution of the nuclear membrane betray an essential permissiveness in cell cycling that is paramount constitutional characterization of a process as “passenger” event in defining malignant transformation. In real terms, incremental progression of the cell cycle is specific hallmark for the events that constitutionally permit the system machinery in mitosis to conclusively establish potential re-setting of events as non-re-replication of the cell cycle in the re-emerging G1 phase of mitotic activity.

Abstract| Introduction| Kinetics| Proportional Representation| Persistence of Progression| Paradox of Permissiveness| Concluding Remarks| References|

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