Permissiveness Paradox in Cell Cycle Progression
Towards Genome Instability and Malignant
Transformation
Volume 2 - Issue 2
Lawrence M Agius*
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- Department Of Pathology, Mater Dei Hospital, Tal-Qroqq, University Of Malta Medical School, Msida, Malta Europe
*Corresponding author:
Lawrence M Agius, Department Of Pathology, Mater Dei Hospital, Tal-Qroqq, University Of Malta Medical
School, Msida, Malta Europe
Received: June 14, 2018; Published: June 19, 2018
DOI: 10.32474/OAJOM.2018.02.000133
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Abstract
Dimensional representation of events actively executing the cell cycle dynamics of progression in carcinogenesis allow for a
paradoxical emergence of highly permissive elements in the establishment of the mitotic spindle and the separation of chromatids.
In such terms, ongoing processes of dissolution of the nuclear membrane betray an essential permissiveness in cell cycling that is
paramount constitutional characterization of a process as “passenger” event in defining malignant transformation. In real terms,
incremental progression of the cell cycle is specific hallmark for the events that constitutionally permit the system machinery in
mitosis to conclusively establish potential re-setting of events as non-re-replication of the cell cycle in the re-emerging G1 phase of
mitotic activity.
Abstract|
Introduction|
Kinetics|
Proportional Representation|
Persistence of Progression|
Paradox of Permissiveness|
Concluding Remarks|
References|