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Lupine Publishers Group

Lupine Publishers

ISSN: 2638-5945

Open Access Journal of Oncology and Medicine

Opinion(ISSN: 2638-5945)

Exosomal and Ectosomal Noncoding RNAs in Cancer– More Than Diagnostic and Prognostic Markers

Volume 2 - Issue 4

Rüdiger Hardeland*

  • Author Information Open or Close
    • Professor of zoology, University of Göttingen, Germany

    *Corresponding author: Rüdiger Hardeland, University of Göttingen, Johann Friedrich Blumenbach Institute of Zoology and Anthropology, Bürgerstr 50, D-37073 Göttingen, Germany

Received: August 31, 2018;   Published: September 18, 2018

DOI: 10.32474/OAJOM.2018.02.000144

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The release of exosomes and ectosomes carrying noncoding RNAs is addressed in the context of cancer, with focus on microRNAs and long noncoding RNAs as well as differences in RNA cargos produced by tumor and nontumor cells. The differential appearance of ncRNAs can be used for diagnostic and prognostic purposes. Beyond these possibilities, the spreading of pathological and beneficial messages deserves particular attention and will gain future importance. Especially the use of exosomes released by cells that overexpress ncRNAs with antitumor properties appears to be a promising strategy

Abstract| Introduction| Cancer Changes Exo- and Ectosomal Contents| A Few Mechanistic Examples of Exo- or EctosomeMediated Changes | Spreading of Pathological and Beneficial Signals | Conclusion| References|


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