Deletion of 9q Causes Chronic BCR-ABL Negative Benign Neutrophilia

Volume 2 - Issue 5

Cherian Verghese*¹, Xiaojin Sha², Talal Khan¹, Emmanouil Alimpertis¹, Hany Meawad², Riddhish Sheth², Feraz Khogeer¹, Anis Toumeh¹, Nauman Siddiqui³ and Robert Booth²

Received: May 03, 2019   Published: May 13, 2019

DOI: 10.32474/OAJOM.2018.02.000149

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF

Abstract

Background: Partial deletions of the long arm of chromosome 9 are associated with various congenital structural and functional defects, developmental delay, mental retardation as well as neuropsychiatric abnormalities. Interstitial deletion of 9q is also a recurring abnormality in malignant myeloid diseases including AML and rarely associated with ALL as well. We present a case of 9q deletion associated with benign leukocytosis in an adult patient.

Case presentation: The case involves a 49-year-old female who presented to our center with a 6-year history of unexplained leukocytosis. Bone marrow evaluation showed metaphase cells to have a deletion of 9q. Bone marrow was also negative for any features of dysplasia or increase in blast cells. The peripheral blood was negative for both JAK2 mutation and BCR-ABL fusion gene product.

Conclusion: Isolated 9q deletion can present as benign chronic neutrophilia. This should be considered after ruling out more common causes of neutrophilia including chronic infections, inflammation, certain medications, hemorrhage, splenectomy, hemolytic anemia and malignant myeloid disorders.

Keywords: 9q Deletion; Benign neutrophilia

Abstract| Introduction| Case Presentation| Discussion| Conclusion| References|