Central Nervous System Manifestation of Multiple Myeloma: A Case Report

Volume 2 - Issue 1

Dinesh Singh*, Prekshi Chowdhary, Swati and Gopal S

Received: June 08, 2018;   Published: June 13, 2018

DOI: 10.32474/OAJOM.2018.02.000128

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Abstract

Multiple myeloma accounts for <1% of all malignancies and Central nervous system (CNS) manifestation of multiple myeloma (MM) is rare. Multiple myelomais characterized by malignant transformation of plasma cells that produces immunoglobulin chains. The accumulation of plasma cells in bone marrow results in clinical features like anaemia, osteolytic lesions, hypocalcaemia, renal failure and immunodeficiency [1,2]. The involvement of central nervous system is very uncommon in multiple myeloma and it may present early or late during the course of disease. The neurological symptoms can be diffuse headache, persistent vomiting, vertigo, weakness in limbs, urinary incontinence etc. Symptoms can be attributed to spinal cord or nerve root compression, peripheral neuropathies, and uremia [3,4]. Likely risk factors of CNS manifestation are unfavourable cytogenetics, high tumour load, low marrow involvement. In this report we describe a patient with CNS involvement after receiving systemic chemotherapy and symptomatic treatment.

Keywords: Central nervous system; Multiple myeloma

Abstract| Case Report| Discussion| Conclusion| References|