Shockwave Therapy in Atherosclerosis
Volume 1 - Issue 2
Michael AB Naafs*
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- Endocrinologist, Health Consultant at Naafs, International Health Consultancy, Rhodoslaan 20,7577KN, Oldenzaal, Netherlands
*Corresponding author:
Michael AB Naafs, Endocrinologist, Health Consultant at Naafs, International Health Consultancy, Rhodoslaan
20,7577KN, Oldenzaal, Netherlands
Received: August 16, 2018; Published: August 21, 2018
DOI: 10.32474/LOJMS.2018.01.000106
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Abstract
In this mini review recent developments in extracorporeal shockwave therapy (ESWT) within the field of atherosclerosis are
discussed. Increased ecpression of growth factors such as endothelial nitric oxide (eNOS) and vascular endothelial growth factors
(VGEFs) are induced by ESWT. IKL, integrin linked kinase, plays a key factor in this process of angiogenesis, believed to be responsible
for the beneficial effects of ESWT. Both cardiac shock wave therapy (CWST) in chronic refractory angina pectoris patients as well as
ESWT in patients with peripheral arterial disease (PAD) show a uniformly, consistent, beneficial effect in all studies available until
now. International standardization of dose-response curves, doses applied, number of sessions and duration of treatment should be
established at first, before starting large RCTs. With that knowledge the future of shockwave therapy in CAD and PAD seems bright.
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