Trace Element Concentrations in the Expressed Prostatic Secretion of Normal and Hyperplastic Prostate

Volume 1 - Issue 3

Vladimir Zaichick*¹ and Sofia Zaichick²

Received: September 03, 2018;   Published: September 07, 2018

DOI: 10.32474/JUNS.2018.01.000112

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Abstract

Objectives: Benign prostatic hyperplasia (BPH) is an internationally important health problem of the man, particularly in developed countries. The aim of this exploratory study was to evaluate whether significant changes in the levels of Zn and some other trace elements of prostatic fluid exist in the hyperplastic prostate.

Methods: Prostatic fluid levels of Br, Fe, Rb, Sr, and Zn were prospectively evaluated in 52 patients with BPH and 38 healthy male inhabitants. Measurements were performed using 109Cd radionuclide-induced energy dispersive X-ray fluorescent microanalysis. Prostatic fluid samples were divided into two portions. One was used for morphological study while the other was intended for trace element analysis.

Results: Mean values ± standard error of means (M±SΕΜ) for concentration (mg/L) of trace element in the prostatic fluid of normal prostate were: Br ±2.86±0.59, Fe 8.30±1.42, Rb 1.16±0.10, Sr 1.27±0.17, and Zn 598±34. It was observed that in the EPF of hyperplastic prostate content of Rb significantly increased whereas content of Zn somewhat decreased in a comparison with those in the EPF of normal prostate.

Conclusion: There are significant changes in trace element contents and their relationships in the fluid of hyperplastic prostate. The alterations in levels of Zn and Rb in the EPF of hyperplastic prostate might demonstrate an involvement of these trace elements in etiology and pathogenesis of BPH. It was supposed that the changes of Zn and Rb levels in the EPF samples can be used as BPH markers.

Keywords: Prostate Cancer; Prostatic Fluid; Trace Elements; Energy-Dispersive X-Ray Fluorescent Analysis

Abstract| Introduction| Material and Methods| Results| Discussion| Conclusion| Declaration| References|