Prevalence and Risk Factors of Post-Transplantation Diabetes Mellitus in Patients after Kidney Allotransplantation in Moscow

Volume 1 - Issue 2

Novikova Maria*, AllazovaSona, Kotenko Oleg and Shilov Eugene

Received: July 05, 2018;;   Published: July 11, 2018

DOI: 10.32474/JUNS.2018.01.000108

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF

Abstract

Purpose: To find out the prevalence, and the risk factors conducive to the development of post-transplantation diabetes mellitus (PTDM) after kidney allotransplantation (KAT).

Methods: The medical histories of 146 recipients of kidney allotransplants received between 1989 and 2014 were reviewed in retrospect. Diabetes mellitus diagnosed before KAT was a criterion for exclusion from the study. Analysed as risk factors were: sex, age, KAT time, and the use of glycocorticoids (GCs), tacrolimus (Tc), and/or cyclosporine A (CcA). The veritability of their influence was assessed using the step-wise linear regression analysis method.

Results: The recipients’ average age was 42.9 +/- 20.2 (х±σ) years at the time of the study. PTDM prevalence in the general group was 21.9% (n=32). Age and the use of calcineurin inhibitors (CNIs) and GCs had the greatest impact on PTDM development (р=0,01).

Keywords: Post-Transplantation Diabetes Mellitus; Kidney Allotransplantation; Glycocorticoids; Calcineurin Inhibitors; Tacrolimus; Cyclosporine

Abbrevations: KAT: Kidney Allotransplantation; PTDM:Post-Transplantation Diabetes Mellitus; GCs: Glycocorticoids; Tc: Tacrolimus; CcA:Cyclosporine A; CNIs: Calcineurin Inhibitors; NODAT: New Onset Diabetes After Transplantation; IGT: Impaired Glucose Tolerance; WHO: World Health Organisation; ADA:American Diabetes Association

Abstract| Introduction| Conclusion| References|