Orchiectomy Versus Goserelin Each Plus Bicalutamide in
Patients with Metastatic Adenocarcinoma of the Prostate:
Adverse Events Highlighted
Volume 2 - Issue 1
Charles Azuwike Odoemene*
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- Alex Ekwueme Federal University Teaching Hospital, Nigeria
*Corresponding author:
Charles Azuwike Odoemene, Senior Lecturer/Consultant Urologist, Alex Ekwueme Federal University
Teaching Hospital, Abakaliki (AEFUTHA), Nigeria
Received:June 24, 2019; Published:July 08, 2019
DOI: 10.32474/JUNS.2019.01.000131
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Abstract
Background: Androgen deprivation therapy (ADT), palliation for advanced/metastatic prostate cancer can be medical or
surgical. This study compares the results of goserelin injection to orchiectomy each in combination with bicalutamide in patients
diagnosed with metastatic adenocarcinoma of the prostate highlighting the adverse events.
Methods: Ninety-six patients with histologically diagnosed adenocarcinoma of the prostate, were prospectively randomized
into two arms. Medical arm patients had subcutaneous goserelin injection plus bicalutamide. Surgical arm patients had bilateral
orchiectomy plus bicalutamide. A nadir serum prostate specific antigen (PSA) of 0.2ng/ml was chosen and response to treatment
was by determining total serum PSA levels at 3 and 6 months. The student’s t test, chi-squared test and Kaplan-Meier survival
analysis were the instruments for statistical analysis.
Results: Follow up was between 6-30 months. There were 11 (23%) and 9 (19%) deaths in the surgical and medical arms
respectively. At 6 months serum PSA levels of ≤ 0.2ng/ml was noted in 44 (92%) and 45 (94%) patients of the medical and surgical
castrations respectively. Anemia, impotence, hot flushes were some of the adverse events noted in both groups during the study
worse with medical castration.
Conclusion: There was no statistical difference between the oncological efficacy and survival of both arms of treatment but a
statistical difference in the adverse events
Keywords: Metastatic adenocarcinoma; Goserelin; Orchiectomy; Bicalutamide
Abstract|
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Materials and Methods|
Statistical Analysis|
Results|
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