Aim: The aim of the study was to study the clinical and functional features of renal dysfunction in conditions of hypertriglyceridemia
and remodeling of the left ventricle.
Materials and Methods: 176 patients with chronic kidney disease (CKD) were examined, 111 of them with hypertriglyceridemia
(HTG) in association with left ventricular hypertrophy (LVH) 1st group and 65 patients with LVH in the absence of HTG, matched
by gender and age. Along with general clinical studies, all patients were assessed for lipid spectrum parameters, measurement
of cystatin C in blood plasma, and indicators of arterial stiffness (augmentation index and stiffness) and echocardiography were
Results: In the 2nd group (HTG + LVH), the number of patients with type 2 diabetes mellitus (DM), a combination of hypertension,
coronary heart disease and gout were significantly higher (p<0.05). Persons with chronic obstructive pulmonary disease, chronic
pyelonephritis and cerebrovascular diseases were significantly more common in the 1st group (p <0.05). In the 2nd group, the value
of BMI [(30.4 ± 5.2 kg/m2 against 28.1±5.7 kg /m2; p = 0.013), the level of systolic blood pressure (BP) (140 ± 19 mm Hg). v. 134 ± 18
mmHg; p = 0.042), thickness of the posterior wall of the left ventricle (LV) (0.98 ± 0.18 cm versus 0.90 ± 0.16 cm; p = 0.008), relative
thickness LV walls (0.385 ± 0.107 units versus 0.357 ± 0.060 units; p=0.032), the number of patients with concentric LV hypertrophy
(29.2; versus 13.5%; p=0.008), total cholesterol content (5.80 (4.87;6.80) mmol/l vs. 4.75 (4.0;5.38) mmol / l; p=0.000); lowdensity
lipoprotein cholesterol (3.56 (3.12;4.63 ) mmol/l versus 3.09 (2.61;3.79) mmol/l; p=0.045) cystatin C (1.25 (1.08;1.70) mg
/ l versus 1.16 (0.99;1.42) mg/l; p=0.026) turned out to be significantly higher, and the calculated glomerular filtration rate (eGFR)
significantly lower (57.0 ± 22 ml / min versus 65.0±23 ml/min; p=0.028)] compared with the 1st group. A positive correlation was
noted between the level of central BP (r=0.264; p=0.003), the augmentation index (r=0.224; p=0.011) and plasma cystatin C (r=
0.486; p=0.000) with the value of the indexed LV myocardium mass (LVMI) in the total sample surveyed. A negative correlation was
recorded between the eGFR and LVMI (r=-0.425; p=0.000).
Conclusion: In the presence of hypertriglyceridemia in patients with left ventricular hypertrophy, cystatin C increases in blood
plasma and GFR decreases with a tendency for augmentation index to increase.
Keywords: Hypertriglyceridemia; Left Ventricular Remodeling; Chronic Kidney Disease; Cystatin C